Hck - hemopoietic cell kinase Gene

Also Known as Bmk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15162

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]

Hck Products (2)

mRNA Protein Name
NM_001172117.1 NP_001165588.1 tyrosine-protein kinase HCK isoform p56Hck
NM_010407.4 NP_034537.2 tyrosine-protein kinase HCK isoform p59Hck

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12235133 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: Inferred from genetic interaction
8125254 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
8125254 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase HCK

  • B cell/myeloid kinase

  • hematopoietic cell kinase

  • p56-HCK/p59-HCK

Hck Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Hck P08103 WAS Homo sapiens P42768
Anti Tag CoIP
12235133
Cross
Hck P08103 WAS Homo sapiens P42768
Protein Kinase Assay
12235133
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175451 MRT-10350 Degrader 99.10% Unkown
HY-181050 DFCI-002-06 Degrader / Unkown
HY-178950 Hck-IN-3 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 Inhibitor / Unkown
HY-175437 MRT-7612 Degrader / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hck NCBI NCBI:3055