Htt - huntingtin Gene

Also Known as Hd; Hdh; IT15; C430023I11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15194

Summary

Enables diazepam binding activity. Involved in several processes, including postsynapse to nucleus signaling pathway; regulation of cAMP-dependent protein kinase activity; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt Products (1)

mRNA Protein Name
NM_010414.3 NP_034544.1 huntingtin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables diazepam binding IMP
IMP: Inferred from mutant phenotype
10082833 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9599014 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
18595722 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17715336 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
16109169 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16109169 MGI
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
17284197 MGI
acts upstream of or within axo-dendritic transport IMP
IMP: Inferred from mutant phenotype
15340079 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
16978870 MGI
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
16403806 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
9398841 MGI
acts upstream of or within citrulline metabolic process IMP
IMP: Inferred from mutant phenotype
17213233 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
11062468 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
9398841 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
16256944 MGI
acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within endosomal transport IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
7550343 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
30391555 MGI
acts upstream of or within grooming behavior IMP
IMP: Inferred from mutant phenotype
10778856 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
10078572 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
10078572 MGI
acts upstream of or within lactate biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
17708681 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
16624677 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
16403806 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
7774020 MGI
acts upstream of or within mitochondrial transport IMP
IMP: Inferred from mutant phenotype
15340079 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15242649 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
7550343 MGI
acts upstream of or within neural plate formation IMP
IMP: Inferred from mutant phenotype
7774020 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
11062468 MGI
NOT acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
10037472 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
7774020 MGI
acts upstream of or within olfactory lobe development IMP
IMP: Inferred from mutant phenotype
12926013 MGI
acts upstream of or within paraxial mesoderm formation IMP
IMP: Inferred from mutant phenotype
16109169 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: Inferred from mutant phenotype
10078572 MGI
acts upstream of or within positive regulation of motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21985783 MGI
acts upstream of or within positive regulation of non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21985783 MGI
involved in postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
20739295 MGI
involved in postsynapse to nucleus signaling pathway IEP
IEP: Inferred from expression pattern
20739295 MGI
involved in postsynapse to nucleus signaling pathway IMP
IMP: Inferred from mutant phenotype
20739295 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
21985783 MGI
acts upstream of or within protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within quinolinate biosynthetic process IMP
IMP: Inferred from mutant phenotype
16697652 MGI
involved in regulation of cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
21768291 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21768291 MGI
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21768291 MGI
involved in regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21768291 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
10196373 MGI
acts upstream of or within response to calcium ion IMP
IMP: Inferred from mutant phenotype
15935052 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
10196365 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11062468 MGI
acts upstream of or within striatum development IMP
IMP: Inferred from mutant phenotype
11030759 MGI
acts upstream of or within urea cycle IMP
IMP: Inferred from mutant phenotype
17213233 MGI
acts upstream of or within vesicle transport along microtubule IDA
IDA: Inferred from direct assay
15242649 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
7774020 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8757264 MGI
located in centriole IDA
IDA: Inferred from direct assay
21985783 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
7647777 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15242649 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25738228 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20739295 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
20739295 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20739295 MGI
located in inclusion body IDA
IDA: Inferred from direct assay
15615787 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
25738228 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin

  • HD protein homolog

  • Huntington disease gene homolog

  • huntington disease protein homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-132579 Tominersen 96.32% Phase 3
HY-156650A Votoplam hydrochloride Modulator / Phase 3
HY-132593 Rovanersen 94.24% Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156650 Votoplam Modulator 99.51% Unkown
HY-16009 Buntanetap 99.71% Unkown
HY-132579A Tominersen sodium 97.36% Unkown
HY-136780 SEN177 Inhibitor 98.76% Unkown
HY-156103 mHTT-IN-2 Inhibitor 99.35% Unkown
HY-177360 RNA splicing modulator-4 Inhibitor 99.08% Unkown
HY-132593A Rovanersen sodium 95.58% Unkown
HY-16009B Buntanetap L-Tartrate 98.93% Unkown
HY-143792 HTT-D3 / Unkown
HY-150236 FITC-labeled Tominersen sodium Inhibitor 97.65% Unkown
HY-10542A (Z)-GW 5074 Inhibitor / Unkown
HY-175136 Chloroguanabenz acetate Agonist / Unkown
HY-184480 PROTAC HTT Degrader-1 Degrader / Unkown
HY-184481 DHPT-PEG2-C2-NH2 Ligand / Unkown
HY-P10822 ED11 Inhibitor / Unkown
HY-RS06490 HTT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W792458 MADAM Ligand / Unkown
HY-RS18021 Htt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24494 Htt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htt NCBI NCBI:3064