Prmt1 - protein arginine N-methyltransferase 1 Gene

Also Known as Mrmt1; Hrmt1l2; 6720434D09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15469

About Prmt1

Chromosome 7: 44,625,413-44,635,992 reverse strand.GRCm39:CM001000.3

This gene has 14 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 13 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues.

Summary

Enables Histone Methyltransferase activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in RNA splicing and cardiac muscle tissue development. Acts upstream of or within in utero embryonic development and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and lung. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products (3)

mRNA	Protein	Name
NM_019830.3	NP_062804.1	protein arginine N-methyltransferase 1 isoform 1
NM_001252476.1	NP_001239405.1	protein arginine N-methyltransferase 1 isoform 2
NM_001252477.1	NP_001239406.1	protein arginine N-methyltransferase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GATOR1 complex binding	IDA IDA: Inferred from direct assay	38006878	MGI
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	16682010	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12529443	MGI
enables protein methyltransferase activity	IMP IMP: Inferred from mutant phenotype	10848611	MGI
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	21652632	MGI
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	38006878	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	30321814	MGI
involved in cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	30321814	MGI
involved in cellular response to methionine	IMP IMP: Inferred from mutant phenotype	38006878	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10848611	MGI
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	38006878	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	30321814	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt1 Protein Structure

AdoMet_MTases

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 1	arginine N-methyltransferase 1 heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 histone-arginine N-methyltransferase PRMT1

Prmt1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Prmt1	Q9JIF0	Axin1	Mus musculus	Q14DJ8	Anti Tag CoIP	21242974
Intra	Prmt1	Q9JIF0	Axin1	Mus musculus	Q14DJ8	Pull Down	21242974
Intra	Prmt1	Q9JIF0	Smad6	Mus musculus	O35182	Anti Tag CoIP	17118358
Intra	Prmt1	Q9JIF0	Khdrbs1	Mus musculus	Q60749	Radiolabeled Methyl	12529443
Intra	Prmt1	Q9JIF0	Khdrbs1	Mus musculus	Q60749	CoIP	12529443
Intra	Prmt1	Q9JIF0	Chtop	Mus musculus	Q9CY57	Confocal	19858291
Intra	Prmt1	Q9JIF0	Chtop	Mus musculus	Q9CY57	Pull Down	19858291

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	99.41%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.93%	Unkown
HY-128717A	GSK3368715 dihydrochloride	Inhibitor	99.96%	Unkown
HY-18962	AMI-1	Inhibitor	98.0%	Unkown
HY-107574	TC-E 5003	Inhibitor	98.06%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.68%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-122096	DCLX069	Inhibitor	98.03%	Unkown
HY-15890	C-7280948	Inhibitor	99.91%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-164456	AMI-408	Inhibitor	/	Unkown
HY-172769	CM112	Degrader	/	Unkown
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Unkown
HY-182297	PRMT1 ligand-1		/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-184653	MS3-123	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown
HY-186045	SKLB06489	Inhibitor	/	Unkown
HY-182298	PRMT1 ligand-Linker Conjugate 1	Ligand	/	Unkown
HY-W191023	4-Amino-N-(2-phenylethyl)benzamide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt1	NCBI	NCBI:3276