2. Gene
  3. Prmt1 - protein arginine N-methyltransferase 1 Gene

Prmt1 - protein arginine N-methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mrmt1; Hrmt1l2; 6720434D09Rik

Gene ID: 15469 | Gene type: protein coding

About Prmt1

Chromosome 7: 44,625,413-44,635,992 reverse strand.GRCm39:CM001000.3

This gene has 14 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 13 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues.

Summary

Enables Histone Methyltransferase activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in RNA splicing and cardiac muscle tissue development. Acts upstream of or within in utero embryonic development and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and lung. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products(3)

mRNA Protein Name
NM_019830.3 NP_062804.1 protein arginine N-methyltransferase 1 isoform 1
NM_001252476.1 NP_001239405.1 protein arginine N-methyltransferase 1 isoform 2
NM_001252477.1 NP_001239406.1 protein arginine N-methyltransferase 1 isoform 3

Prmt1 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (73 - 173)

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  • 353 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 1

arginine N-methyltransferase 1

heterogeneous nuclear ribonucleoproteins methyltransferase-like 2

histone-arginine N-methyltransferase PRMT1

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-18962 AMI-1 Inhibitor ≥98.0% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-12970 EPZ020411 Inhibitor 98.06% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-122096 DCLX069 Inhibitor 98.38% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt1 NCBI NCBI:3276