DDT - D-dopachrome tautomerase Gene

Also Known as D-DT; DDCT; MIF2; MIF-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1652

About DDT

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,971,370-23,980,504 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 174 orthologues and 2 paralogues. Broad expression in liver (RPKM 108.4), kidney (RPKM 65.2) and 23 other tissues.

Summary

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]

DDT Products (4)

mRNA Protein Name
NM_001084392.3 NP_001077861.1 D-dopachrome decarboxylase isoform a
NM_001355.4 NP_001346.1 D-dopachrome decarboxylase isoform a
NM_001381852.2 NP_001368781.1 D-dopachrome decarboxylase isoform b
NM_001397485.1 NP_001384414.1 D-dopachrome decarboxylase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-dopachrome decarboxylase activity IDA
IDA: Inferred from direct assay
8267597 GOA
enables D-dopachrome decarboxylase activity IMP
IMP: Inferred from mutant phenotype
9480844 GOA
enables cytokine receptor binding IDA
IDA: Inferred from direct assay
21817065 GOA
enables phenylpyruvate tautomerase activity IDA
IDA: Inferred from direct assay
21817065 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
21817065 GOA
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21817065 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
21817065 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21817065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDT Protein Structure

MIF

MIF: Macrophage migration inhibitory factor (MIF) (2 - 116)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

D-dopachrome decarboxylase

  • phenylpyruvate tautomerase II

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13690 Mitotane Inducer 99.94% Yes
HY-13690R Mitotane (Standard) Inducer 99.99% Unkown

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-41465 4-Chlorobenzoic acid 99.37% Unkown
HY-B1986 p,p'-DDE Antagonist 99.91% Unkown
HY-B1984 p,p'-DDD 99.37% Unkown
HY-13690S1 Mitotane-13C6 98.62% Unkown
HY-B1873S Methoxychlor-d6 98.22% Unkown
HY-B1970S o,p'-DDT-d8 95.00% Unkown
HY-B1986S p,p'-DDE-d8 99% Unkown
HY-121779 o,p'-DDE 99.95% Unkown
HY-122551 Chlorfenethol / Unkown
HY-13690S2 Mitotane-d8 / Unkown
HY-13690S3 Mitotane-13C12 Inducer / Unkown
HY-159086 RGB097 Inhibitor / Unkown
HY-159087 RGB110 / Unkown
HY-181912 D-DT/MIF-1-IN-1 Inhibitor / Unkown
HY-B1984S p,p'-DDD-d8 / Unkown
HY-RS03627 DDT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03628 DDTL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012077 3'-NH2-ddT / Unkown
HY-B1970 o,p'-DDT Activator / Unkown
HY-RS17792 Ddt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24260 Ddt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W078592 1-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene / Unkown
HY-W750297 p,p'-DDD-13C12 / Unkown
HY-W753141 p,p'-DDE-13C12 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DDT RGD RGD:61923
Mus musculus DDT MGD MGI:1298381
Others DDT NCBI