Sgk1 - serum/glucocorticoid regulated kinase 1 Gene

Also Known as Sgk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20393

About Sgk1

Chromosome 10: 21,758,083-21,875,802 forward strand.GRCm39:CM001003.3

This gene has 13 transcripts (splice variants), 214 orthologues, 13 paralogues and is associated with 8 phenotypes. Ubiquitous expression in colon adult (RPKM 16.7), large intestine adult (RPKM 16.3) and 28 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and Proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]

Sgk1 Products (6)

mRNA Protein Name
NM_001161847.2 NP_001155319.1 serine/threonine-protein kinase Sgk1 isoform b
NM_011361.3 NP_035491.1 serine/threonine-protein kinase Sgk1 isoform e
NM_001161848.2 NP_001155320.1 serine/threonine-protein kinase Sgk1 isoform b
NM_001161849.2 NP_001155321.1 serine/threonine-protein kinase Sgk1 isoform c
NM_001161850.2 NP_001155322.1 serine/threonine-protein kinase Sgk1 isoform d
NM_001161845.2 NP_001155317.2 serine/threonine-protein kinase Sgk1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15665527 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15383658 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
15383658 MGI
acts upstream of or within cellular response to aldosterone IDA
IDA: Inferred from direct assay
20427473 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15383658 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sgk1 Protein Structure

STKc_SGK1

STKc_SGK1: cd05602 (182 - 520)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Sgk1

  • serum and glucocorticoid-dependent protein kinase

Sgk1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sgk1 Q9WVC6 Tsc22d3 Mus musculus Q9Z2S7-3
Anti Tag CoIP
19380724
Intra
Sgk1 Q9WVC6 Tsc22d3 Mus musculus Q9Z2S7-3
Anti Bait CoIP
19380724
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15192 GSK 650394 Inhibitor 99.76% Unkown
HY-15193 EMD638683 Inhibitor 99.94% Unkown
HY-18607 SGK1-IN-1 Inhibitor 99.57% Unkown
HY-167832 PT109 Inhibitor 99.20% Unkown
HY-135893 SGK1-IN-2 Inhibitor 98.36% Unkown
HY-142686A SGK1-IN-3 hydrochloride Inhibitor 96.65% Unkown
HY-15193B EMD638683 (S-Form) Inhibitor 99.95% Unkown
HY-15193A EMD638683 (R-Form) Inhibitor 99.86% Unkown
HY-185412 SGK1-IN-9 Inhibitor / Unkown
HY-176823 PROTAC SGK3 degrader-2 Degrader / Unkown
HY-184333 SGK1-IN-10 Inhibitor / Unkown
HY-170933 SGK1-IN-6 Inhibitor / Unkown
HY-142686 SGK1-IN-3 Inhibitor / Unkown
HY-128221 SGK1-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgk1 NCBI NCBI:6446