ERF - ETS2 repressor factor Gene

Homo sapiens

Also known as PE2; CRS4; PE-2; CHYTS

Gene ID: 2077 | Gene type: protein coding

About ERF

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,247,569-42,255,128 (from NCBI)

This gene has 7 transcripts (splice variants), 249 orthologues, 28 paralogues and is associated with 6 phenotypes. Ubiquitous expression in kidney (RPKM 13.9), fat (RPKM 12.9) and 25 other tissues.

Summary

ETS2 is a transcription factor and protooncogene involved in development, Apoptosis, and the regulation of Telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

ERF Products(4)

mRNA	Protein	Name
NM_001301035.2	NP_001287964.1	ETS domain-containing transcription factor ERF isoform 2
NM_001308402.2	NP_001295331.1	ETS domain-containing transcription factor ERF isoform 2
NM_001312656.2	NP_001299585.1	ETS domain-containing transcription factor ERF isoform 2
NM_006494.4	NP_006485.2	ETS domain-containing transcription factor ERF isoform 1

ERF Protein Structure

Ets

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

ETS domain-containing transcription factor ERF

Related Diseases

Diseases

Alias

Chitayat Syndrome

CHYTS

Bronchomalacia

Craniosynostosis 4

CRS4	Craniosynostosis, Type 4

Lambdoid Synostosis

Craniosynostosis, Lambdoidal

Synostotic Posterior Plagiocephaly

Non-Syndromic Sagittal Craniosynostosis

Isolated Sagittal Craniosynostosis	Isolated Scaphocephaly
Non-Syndromic Sagittal Suture Synostosis

Craniosynostosis 1

CRS	Congenital Rubella Syndrome
Craniostenosis	Congenital Rubella
CRS1	Craniosynostosis, Type 1
Rubella Congenital	Fetal Rubella Syndrome
Mother-To-Child Transmission Of Rubella Syndrome	Rubella, Congenital
Craniosynostosis	Gregg Syndrome

Crouzon Syndrome

Crouzon Craniofacial Dysostosis	Craniofacial Dysostosis
Cfd1	Craniofacial Dysostosis Type 1
Crouzon Disease	Crouzon'S Disease
Craniofacial Dysostosis, Type I	Craniofacial Dysarthrosis
Craniofacial Dysostosis Syndrome	CS
Craniofacial Dysostosis Type I	Vogt Cephalosyndactyly

Urethral False Passage

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Septicemic Plague

Plague, Septicemic

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Pneumonic Plague

Primary Pneumonic Plague	Secondary Pneumonic Plague
Plague	Plague, Pneumonic
Plague Pneumonia	Plague Of Lung
Pulmonary Plague	Pneumonia Due To Yersinia Pestis

Nasal Cavity Lymphoma

Lymphoma Of Nasal Cavity

Lymphoma Of The Nasal Cavity

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Epstein-Barr Virus Hepatitis

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

Brachydactyly

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150090	SRI-41315	Activator	99.94%	Unkown
HY-153176	PAT-IN-1	Inhibitor	/	Unkown
HY-153177	PAT-IN-2	Inhibitor	/	Unkown
HY-RS04488	ERF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ERF	RGD	RGD:1311991
Bos taurus	ERF	VGNC	VGNC:28576
Macaca mulatta	ERF	VGNC	VGNC:108146
Canis familiaris	ERF	VGNC	VGNC:40447
Felis catus	ERF	VGNC	VGNC:61936
Mus musculus	ERF	MGD	MGI:109637
Macaca fascicularis	ERF	NCBI
Canis lupus familiaris	ERF	NCBI
Susscrofa domestica	ERF	NCBI
Leporidae	ERF	NCBI
Others	ERF	NCBI

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