ERF - ETS2 repressor factor Gene

Also Known as PE2; CRS4; PE-2; CHYTS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2077

About ERF

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,247,569-42,255,128 (from NCBI)

This gene has 7 transcripts (splice variants), 249 orthologues, 28 paralogues and is associated with 6 phenotypes. Ubiquitous expression in kidney (RPKM 13.9), fat (RPKM 12.9) and 25 other tissues.

Summary

ETS2 is a transcription factor and protooncogene involved in development, Apoptosis, and the regulation of Telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

ERF Products (4)

mRNA	Protein	Name
NM_001301035.2	NP_001287964.1	ETS domain-containing transcription factor ERF isoform 2
NM_001308402.2	NP_001295331.1	ETS domain-containing transcription factor ERF isoform 2
NM_001312656.2	NP_001299585.1	ETS domain-containing transcription factor ERF isoform 2
NM_006494.4	NP_006485.2	ETS domain-containing transcription factor ERF isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7588608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7588608	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERF Protein Structure

Ets

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
ETS domain-containing transcription factor ERF

ERF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chitayat Syndrome	CHYTS Bronchomalacia
Craniosynostosis 4	CRS4 Craniosynostosis, Type 4
Lambdoid Synostosis	Craniosynostosis, Lambdoidal Synostotic Posterior Plagiocephaly
Non-Syndromic Sagittal Craniosynostosis	Isolated Sagittal Craniosynostosis Isolated Scaphocephaly Non-Syndromic Sagittal Suture Synostosis
Craniosynostosis 1	CRS Congenital Rubella Syndrome Craniostenosis Congenital Rubella CRS1 Craniosynostosis, Type 1 Rubella Congenital Fetal Rubella Syndrome Mother-To-Child Transmission Of Rubella Syndrome Rubella, Congenital Craniosynostosis Gregg Syndrome
Crouzon Syndrome	Crouzon Craniofacial Dysostosis Craniofacial Dysostosis Cfd1 Craniofacial Dysostosis Type 1 Crouzon Disease Crouzon'S Disease Craniofacial Dysostosis, Type I Craniofacial Dysarthrosis Craniofacial Dysostosis Syndrome CS Craniofacial Dysostosis Type I Vogt Cephalosyndactyly
Urethral False Passage
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Septicemic Plague	Plague, Septicemic
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Nasal Cavity Lymphoma	Lymphoma Of Nasal Cavity Lymphoma Of The Nasal Cavity
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Epstein-Barr Virus Hepatitis
Gaucher Disease, Type Ii	GD2 Gd Ii Gaucher Disease, Acute Neuronopathic Type Gaucher Disease Type 2 Gaucher Disease Type Ii Gaucher'S Disease Type Ii Infantile Cerebral Gaucher Disease Acute Neuronopathic Gaucher Disease Gd 2 Gaucher Disease, Infantile Cerebral Gaucher Disease 2 Type 2 Gaucher Disease Gaucher Disease, Type 2
Ross River Fever	Ross River Virus Disease Ross River Virus Infection
Papillary Transitional Carcinoma	Papillary Transitional Cell Carcinoma
Brachydactyly
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150090	SRI-41315	Activator	99.68%	Unkown
HY-W923189	Neral		97.87%	Unkown
HY-163938	PROTAC erf3a Degrader-1	Degrader	99.44%	Unkown
HY-177569	NVS1.1	Degrader	/	Unkown
HY-177757	NVS2.1	Degrader	99.9%	Unkown
HY-RS04554	ETF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120743	Triplin		/	Unkown
HY-153176	PAT-IN-1	Inhibitor	/	Unkown
HY-153177	PAT-IN-2	Inhibitor	/	Unkown
HY-163938A	PROTAC erf3a Degrader-2		/	Unkown
HY-163960	NH2-Ph-NH-cyclohexane-NH-Boc		/	Unkown
HY-163961A	Thalidomide-NH-cyclohexane-NH-Ph-NH2		/	Unkown
HY-RS04488	ERF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16710	Erf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20729	Etf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23145	Erf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ERF	RGD	RGD:1311991
Bos taurus	ERF	VGNC	VGNC:28576
Macaca mulatta	ERF	VGNC	VGNC:108146
Canis familiaris	ERF	VGNC	VGNC:40447
Felis catus	ERF	VGNC	VGNC:61936
Mus musculus	ERF	MGD	MGI:109637
Others	ERF	NCBI