Ucp1 - uncoupling protein 1 (mitochondrial, proton carrier) Gene

Also Known as Ucp; Slc25a7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22227

Summary

Enables long-chain fatty acid binding activity; Oxidative Phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including cellular response to cold; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation and regulation of transcription by RNA polymerase II. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; adrenal gland; submandibular gland; testis; and thymus. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ucp1 Products (1)

mRNA Protein Name
NM_009463.3 NP_033489.1 mitochondrial brown fat uncoupling protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables long-chain fatty acid binding IDA
IDA: Inferred from direct assay
23063128 MGI
enables oxidative phosphorylation uncoupler activity IDA
IDA: Inferred from direct assay
12910269 MGI
enables oxidative phosphorylation uncoupler activity IMP
IMP: Inferred from mutant phenotype
20416274 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12910269 MGI
enables purine ribonucleotide binding IDA
IDA: Inferred from direct assay
23063128 MGI
Biological Process GO Annotation Evidence References Source
involved in adaptive thermogenesis IMP
IMP: Inferred from mutant phenotype
9139827 MGI
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
28763438 MGI
involved in brown fat cell differentiation IEP
IEP: Inferred from expression pattern
15567149 MGI
involved in cellular response to cold IDA
IDA: Inferred from direct assay
28763438 MGI
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
23063128 MGI
involved in cellular response to hormone stimulus IMP
IMP: Inferred from mutant phenotype
27027295 MGI
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
27027295 MGI
involved in diet induced thermogenesis IMP
IMP: Inferred from mutant phenotype
19187776 MGI
involved in mitochondrial transmembrane transport IDA
IDA: Inferred from direct assay
23063128 MGI
involved in mitochondrial transmembrane transport IMP
IMP: Inferred from mutant phenotype
20416274 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28630339 MGI
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
23063128 MGI
involved in regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
20416274 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17670746 MGI
involved in response to nutrient levels IMP
IMP: Inferred from mutant phenotype
19187776 MGI
involved in response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
19187776 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial envelope IDA
IDA: Inferred from direct assay
12910269 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
23063128 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11940593 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial brown fat uncoupling protein 1

  • UCP 1

  • solute carrier family 25 member 7

  • thermogenin

  • uncoupling protein 1, mitochondrial

  • uncoupling protein, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107574 TC-E 5003 98.06% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-110148 WWL113 Inhibitor 99.72% Unkown
HY-N0260 Epmedin C 99.47% Unkown
HY-P2917 Glycerol kinase, microorganism Inhibitor 98.00% Unkown
HY-135115 Oleuropein Aglycone Inhibitor 98.46% Unkown
HY-138207 N-Oleoyl-L-phenylalanine 99.4% Unkown
HY-114557 NSC 90469 99.41% Unkown
HY-129692 Withanone Inhibitor 93.28% Unkown
HY-133095 BML-260 Activator 99.65% Unkown
HY-153813 Z16078526 Modulator 98.12% Unkown
HY-148973 ZW290 Inhibitor 99.60% Unkown
HY-RS16955 Ucp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101824 NC-2100 Activator / Unkown
HY-11032 SM-350300 / Unkown
HY-114557R NSC 90469 (Standard) / Unkown
HY-139994 XN methyl pyrazole / Unkown
HY-176148 ZGL-18 / Unkown
HY-183094 AM73 / Unkown
HY-183095 AM79 / Unkown
HY-183096 AM31 / Unkown
HY-183097 AM89 / Unkown
HY-186011 CPAG-1 Activator / Unkown
HY-RS15410 UCP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153812 AST 7062601 / Unkown
HY-RS23398 Ucp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ucp1 NCBI NCBI:7350