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Xbp1 - X-box binding protein 1 Gene

Also Known as TREB5; XBP-1; TREB-5; D11Ertd39e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22433

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; lipid homeostasis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; exocrine system development; and positive regulation of proteasomal protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Xbp1 Products (2)

mRNA	Protein	Name
NM_001271730.1	NP_001258659.1	X-box-binding protein 1 isoform XBP1(S)
NM_013842.3	NP_038870.2	X-box-binding protein 1 isoform XBP1(U)

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20408817	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23152784	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17612490	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	20408817	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	20348926	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8657566	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18556558	MGI
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	20408817	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	23623498	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	23529610	MGI
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	24753614	MGI
involved in cellular response to fructose stimulus	IDA IDA: Inferred from direct assay	18556558	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	17612490	MGI
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	18556558	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	20348926	MGI
involved in cellular response to interleukin-4	IDA IDA: Inferred from direct assay	12612580	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12612580	MGI
involved in cellular response to nutrient	IDA IDA: Inferred from direct assay	20348926	MGI
involved in cellular response to peptide hormone stimulus	IDA IDA: Inferred from direct assay	23623498	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	18556558	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	16332684	MGI
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	14559994	MGI
involved in endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23529610	MGI
acts upstream of or within epithelial cell maturation involved in salivary gland development	IMP IMP: Inferred from mutant phenotype	16362047	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	16362047	MGI
involved in fatty acid homeostasis	IMP IMP: Inferred from mutant phenotype	18556558	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	16362047	MGI
involved in intracellular triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	18556558	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	19328063	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	10652269	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10652269	MGI
involved in negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	17612490	MGI
involved in neuron development	IDA IDA: Inferred from direct assay	24753614	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23623498	MGI
involved in positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	10652269	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	12612580	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12612580	MGI
involved in positive regulation of lactation	IMP IMP: Inferred from mutant phenotype	23623498	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23152784	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18556558	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10652269	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	24753614	MGI
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24753614	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23623498	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	12612580	MGI
involved in response to insulin-like growth factor stimulus	IDA IDA: Inferred from direct assay	17612490	MGI
involved in sterol homeostasis	IMP IMP: Inferred from mutant phenotype	18556558	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17612490	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24753614	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16332684	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16332684	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
X-box-binding protein 1	tax-responsive element-binding protein 5 homolog

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-104040	MKC8866	Inhibitor	99.95%	Phase 2

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139214	IXA4	Inhibitor	98.92%	Unkown
HY-100355	C18-Ceramide (d18:1/18:0)		99.95%	Unkown
HY-103248	Toyocamycin		99.27%	Unkown
HY-124293	AA147	Activator	99.81%	Unkown
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-W018161	Hexadecanedioic acid	Inhibitor	98.0%	Unkown
HY-139212	IXA6	Activator	99.29%	Unkown
HY-W020952	Palladium(Ⅱ) acetylacetonate		98.2%	Unkown
HY-161672	G-5758	Inhibitor	98.91%	Unkown
HY-176040	IXA62	Inhibitor	99.55%	Unkown
HY-U00460	3,6-DMAD hydrochloride	Inhibitor	99.50%	Unkown
HY-124646	KIRA-7	Inhibitor	99.09%	Unkown
HY-18509	IRE1α kinase-IN-2	Inhibitor	99.24%	Unkown
HY-178946	IA107	Inhibitor	98.14%	Unkown
HY-RS15865	XBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123996	3-Ethoxy-5,6-dibromosalicylaldehyde		/	Unkown
HY-135945	Dihydrocoptisine		/	Unkown
HY-145425	PAIR2		/	Unkown
HY-158386	IRE1a-IN-1	Inhibitor	/	Unkown
HY-158393	IRE1a-IN-2	Inhibitor	/	Unkown
HY-168843	PSP205	Inducer	/	Unkown
HY-173497	IRE1-IN-2	Inhibitor	/	Unkown
HY-181886	AK177		/	Unkown
HY-U00460B	3,6-DMAD dihydrochloride	Inhibitor	/	Unkown
HY-W018161S	Hexadecanedioic acid-d28		99.21%	Unkown
HY-138844	3-AP-Me	Activator	/	Unkown
HY-RS16677	Xbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23112	Xbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xbp1	NCBI	NCBI:7494