country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189800

Copy Link Print Information

GRP78-IN-4

GRP78-IN-4 is a GRP78 inhibitor with an IC₅₀ value of 1.1 μM. GRP78-IN-4 induces the unfolded protein response through the PERK/eIF2α/ATF4/CHOP and IRE1/XBP1s signaling pathways. GRP78-IN-4 exhibits cytotoxicity in cancer cell lines. GRP78-IN-4 can be used for research on lung cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₂H₂₈N₄O₃S
Masse moléculaire:428.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GRP78-IN-4 Chemical Structure

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Grp78

1.1 μM (IC₅₀)

eIF2-α

Voir tous les produits spécifiques à Isoform HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	3.2 μM	Cytotoxicity against human A549 lung cancer cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human A549 lung cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.	acs.jmedchem.6c01794

In Vitro

GRP78-IN-4 (Compound 12) (72 h) selectively kills A549 lung cancer cells with a CC₅₀ of 3.2 μM^[1].
GRP78-IN-4 has an IC₅₀ of 0.6 μM for GRP78 SBD and 1.2 μM for GRP78 FL^[1].
GRP78-IN-4 (0-16 μM) activates the PERK and IRE1 branches of the unfolded protein response (UPR) in A549 cells, increases the phosphorylation level of eIF2α, and upregulates the expression of ATF4 and CHOP as well as the XBP1 splicing product XBP1s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Masse moléculaire 428.55
Formule C₂₂H₂₈N₄O₃S
SMILES

O=C(C(N1)=CC2=C1C=CC=C2OC)N[C@@H](CCCC)C(NC3=NC(C(C)C)=CS3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhu X, et al. Development of Isoform-Selective GRP78 Inhibitors from a Direct-to-Biology Strategy. Journal of Medicinal Chemistry. 2026 Sep 24;69(18):21421-39.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis