AAK1 - AP2 associated kinase 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22848

About AAK1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,457,997-69,643,739 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 7.8), thyroid (RPKM 4.9) and 24 other tissues.

Summary

This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating Infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020]

AAK1 Products (3)

mRNA Protein Name
NM_001371577.1 NP_001358506.1 AP2-associated protein kinase 1 isoform 3
NM_014911.5 NP_055726.4 AP2-associated protein kinase 1 isoform 1
NM_001371575.1 NP_001358504.1 AP2-associated protein kinase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
17494869 GOA
enables Notch binding IDA
IDA: Inferred from direct assay
21464124 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22645275 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
21464124 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17494869 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
21464124 GOA
involved in regulation of clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
18657069 GOA
involved in regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
17494869 GOA
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
18657069 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AAK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (47 - 307)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 961 a.a.
Protein Preferred Names Protein Names

AP2-associated protein kinase 1

  • adaptor-associated kinase 1

AAK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811146 AAK1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P89855 AAK1 Antibody (YA9199) WB, IP, ELISA human

Related Diseases

Diseases Alias
Ebola Hemorrhagic Fever

  • Ebola Virus Disease

  • Viral Hemorrhagic Fever

  • Hemorrhagic Fever, Ebola

  • Ehf

  • Ebola Fever

  • Ebola

  • Hemorrhagic Fevers, Viral

  • Ebola Haemorrhagic Fever

  • Ebod - [Ebola Disease]

  • Evd - [Ebola Virus Disease]

  • Ebola Virus Haemorrhagic Fever

  • Vhf - [Viral Haemorrhagic Fever] Nos

  • Viral Haemorrhagic Fever, Not Otherwise Specified
Critical Covid-19
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Rabies

  • Lyssa

  • Hydrophobia

  • St Hubert Disease
Cone-Rod Dystrophy 19

  • CORD19

  • Dystrophy, Cone-Rod, Type 19
Hepatitis C

  • Chronic Hepatitis C

  • Hepatitis C Infection

  • Hepatitis Nona Nonb

  • Nanbh

  • Viral Hepatitis C

  • Hepatitis C Chronic

  • Hepatitis C, Chronic

  • Chronic Type C Viral Hepatitis

  • Chronic Hcv - [Hepatitis C Virus] Infection

  • Hepatitis C Nos

  • Hepatitis C Infection Nos

  • Hepatitis C-Related Cirrhosis

  • Type C Viral Hepatitis

  • Hep C Nos
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-134829 BMS-986176 98.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-123940 SGC-AAK1-1 98.47% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171770 dAurAB5 Inhibitor 99.03% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-115868 BMS-911172 99.49% Unkown
HY-135871 BMT-124110 99.15% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149054 GSK-3β inhibitor 13 Inhibitor 99.74% Unkown
HY-147083 SGC-AAK1-1N Inhibitor 97.9% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-117453 BMS-901715 / Unkown
HY-120179A LP-922761 hydrate 98.0% Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-176705 AAK1-IN-9 Inhibitor / Unkown
HY-162388 TIM-098a Inhibitor / Unkown
HY-145838 AAK1-IN-4 / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-144301 AAK1-IN-2 / Unkown
HY-144302A AAK1-IN-3 TFA / Unkown
HY-185187 AAK1-IN-12 Inhibitor / Unkown
HY-176706 AAK1-IN-10 Inhibitor / Unkown
HY-144302 AAK1-IN-3 / Unkown
HY-101290 BMT-090605 Inhibitor 98.27% Unkown
HY-145839 AAK1-IN-5 / Unkown
HY-159931 HW161023 Inhibitor / Unkown
HY-144301A AAK1-IN-2 TFA / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-174213 AAK1-IN-7 Inhibitor / Unkown
HY-175536 AAK1-IN-11 Inhibitor / Unkown
HY-174214 AAK1-IN-8 Inhibitor / Unkown
HY-159879 AAK1-IN-6 Inhibitor / Unkown
HY-120092 BMT-046091 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AAK1 VGNC VGNC:59451
Canis familiaris AAK1 VGNC VGNC:37410
Mus musculus AAK1 MGD MGI:1098687
Rattus norvegicus AAK1 RGD RGD:1305520
Macaca mulatta AAK1 VGNC VGNC:82094
Bos taurus AAK1 VGNC VGNC:25443
Others AAK1 NCBI