MAPRE3 - microtubule associated protein RP/EB family member 3 Gene

Also Known as EB3; RP3; EBF3; EBF3-S

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22924

About MAPRE3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,970,637-27,027,219 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 2 paralogues. Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

MAPRE3 Products (3)

mRNA	Protein	Name
NM_001303050.2	NP_001289979.1	microtubule-associated protein RP/EB family member 3 isoform 1
NM_001410716.1	NP_001397645.1	microtubule-associated protein RP/EB family member 3 isoform 2
NM_012326.4	NP_036458.2	microtubule-associated protein RP/EB family member 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644998	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	26323690	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	26323690	GOA
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	23159740	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cytoplasmic microtubule	IDA IDA: Inferred from direct assay	10644998	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	10644998	GOA
located in mitotic spindle astral microtubule end	IDA IDA: Inferred from direct assay	23509069	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10644998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE3 Protein Structure

EB1

0
100
200
281 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein RP/EB family member 3	APC binding protein

MAPRE3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	SLC	27107012
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Y2H Array	31515488
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Validated Y2H	25416956
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Y2H Prey Pooling	25416956
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Y2H	27107012
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	BFG-2H	27107012
Intra	MAPRE3	Q9UPY8	MAPRE1	Homo sapiens	Q15691	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	CRTAC1	Homo sapiens	Q9NQ79	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	CRTAC1	Homo sapiens	Q9NQ79	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	GTF2F2	Homo sapiens	P13984	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	GTF2F2	Homo sapiens	P13984	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	APC2	Homo sapiens	O95996	Pull Down	10644998
Intra	MAPRE3	Q9UPY8	APC2	Homo sapiens	O95996	Confocal	10644998
Intra	MAPRE3	Q9UPY8	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	HROB	Homo sapiens	Q8N3J3-3	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	HROB	Homo sapiens	Q8N3J3-3	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	FOXD4L1	Homo sapiens	Q9NU39	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	FOXD4L1	Homo sapiens	Q9NU39	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	SPMIP2	Homo sapiens	Q96LM5	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	SPMIP2	Homo sapiens	Q96LM5	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ZNF547	Homo sapiens	Q8IVP9	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ZNF547	Homo sapiens	Q8IVP9	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	FOXD4L4	Homo sapiens	Q8WXT5	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	FOXD4L4	Homo sapiens	Q8WXT5	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	POU4F1	Homo sapiens	Q01851	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	POU4F1	Homo sapiens	Q01851	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	TRAIP	Homo sapiens	Q9BWF2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	CCSER1	Homo sapiens	Q9C0I3-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	CCSER1	Homo sapiens	Q9C0I3-2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	C20orf202	Homo sapiens	A1L168	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	C20orf202	Homo sapiens	A1L168	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	LAP3	Homo sapiens	P28838	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	LAP3	Homo sapiens	P28838	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	TRIM14	Homo sapiens	Q14142	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	TRIM14	Homo sapiens	Q14142	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	MAPRE3	Q9UPY8	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	MAPRE3	Q9UPY8	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	MAPRE3	Q9UPY8	MAPT	Homo sapiens	P10636	Affinity Chrom	30668577
Intra	MAPRE3	Q9UPY8	PSMB1	Homo sapiens	P20618	Y2H Prey Pooling	25416956
Intra	MAPRE3	Q9UPY8	KNSTRN	Homo sapiens	Q9Y448	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	KNSTRN	Homo sapiens	Q9Y448	Validated Y2H	32296183
Intra	MAPRE3	Q9UPY8	KNSTRN	Homo sapiens	Q9Y448	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	EIF4E2	Homo sapiens	O60573	Validated Y2H	25416956
Intra	MAPRE3	Q9UPY8	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	MAPRE3	Q9UPY8	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	ANKRD1	Homo sapiens	Q15327	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	ANKRD1	Homo sapiens	Q15327	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	FAM161B	Homo sapiens	Q96MY7	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	FAM161B	Homo sapiens	Q96MY7	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	MAPRE3	Q9UPY8	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	MAPRE3	Q9UPY8	PSRC1	Homo sapiens	Q6PGN9	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	PSRC1	Homo sapiens	Q6PGN9	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	MAPRE3	Q9UPY8	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	MAPRE3	Q9UPY8	MAPRE2	Homo sapiens	Q15555	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	MAPRE2	Homo sapiens	Q15555	Y2H Array	31515488
Intra	MAPRE3	Q9UPY8	MAPRE2	Homo sapiens	Q15555	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	APPL2	Homo sapiens	Q8NEU8	Y2H Array	25814554
Intra	MAPRE3	Q9UPY8	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Cross	MAPRE3	Q9UPY8	Map1b	Mus musculus	P14873	FRAP	23572079
Cross	MAPRE3	Q9UPY8	Map1b	Mus musculus	P14873	Pull Down	23572079
Cross	MAPRE3	Q9UPY8	Map1b	Mus musculus	P14873	Anti Bait CoIP	23572079
Cross	MAPRE3	Q9UPY8	Srcin1	Mus musculus	Q9QWI6-2	Pull Down	19146815
Cross	MAPRE3	Q9UPY8	Srcin1	Mus musculus	Q9QWI6-2	Fluorescence	19146815
Cross	MAPRE3	Q9UPY8	Srcin1	Mus musculus	Q9QWI6-2	IF	19146815
Intra	MAPRE3	Q9UPY8	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	GAS2L2	Homo sapiens	Q8NHY3	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	GAS2L2	Homo sapiens	Q8NHY3	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	MAPRE3	Q9UPY8	JUN	Homo sapiens	P05412	TAP	20195357
Intra	MAPRE3	Q9UPY8	KLHDC7B	Homo sapiens	Q96G42	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	KLHDC7B	Homo sapiens	Q96G42	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	MARCHF7	Homo sapiens	Q9H992	Y2H Prey Pooling	32296183
Intra	MAPRE3	Q9UPY8	MARCHF7	Homo sapiens	Q9H992	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Array	32296183
Intra	MAPRE3	Q9UPY8	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPRE3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75275	EB3/MAPRE3 Protein, Human (His)	Q9UPY8-1 (M1-Y281)	≥ 95%, as determined by reducing SDS-PAGE.

MAPRE3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82030	EB3 Antibody (YA1775)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Distal Hereditary Motor Neuronopathy Type 7	Dhmn7 Dhmnvpy Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Neuronopathy, Distal Hereditary Motor, Type Viib	HMN7B Hmn Viib Dhmn7b Neuropathy, Distal Hereditary Motor, Type Viib Distal Hereditary Motor Neuronopathy Type 7b Distal Hereditary Motor Neuropathy Type Viib Neuronopathy, Distal Hereditary Motor, Type 7b Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib Lower Motor Neuron Disease, Dynactin Type Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b Harper-Young Myopathy Neuronopathy, Distal Hereditary Motor, 7b Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib Lower Motor Neuron Disease Dynactin Type Plmnd Progressive Lower Motor Neuron Disease Neuropathy, Motor, Distal, Hereditary, Type Viib
Marburg Hemorrhagic Fever	Marburg Virus Disease Marburg Disease Green Monkey Disease Mhf Vervet Monkey Disease Mard - [Marburg Disease] Mvd - [Marburg Virus Disease] Marburg Haemorrhagic Fever Mhf - [Marburg Haemorrhagic Fever]
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Arthrogryposis, Distal, Type 4	Distal Arthrogryposis Type 4 DA4 Daiid Arthrogryposis-Severe Scoliosis Syndrome Distal Arthrogryposis Type Iid Arthrogryposis With Severe Scoliosis Arthrogryposis, Distal, Type Iid
Bolivian Hemorrhagic Fever	Machupo Hemorrhagic Fever Hemorrhagic Fever, Bolivian Bhf - [Bolivian Haemorrhagic Fever] Machupo Haemorrhagic Fever
Omsk Hemorrhagic Fever	Ohf Hemorrhagic Fever, Omsk Ohf - [Omsk Haemorrhagic Fever] Spring-Fall Haemorrhagic Fever
Nipah Virus Encephalitis	Equine Morbillivirus
Perry Syndrome	Parkinsonism With Alveolar Hypoventilation And Mental Depression PERRYS
Helsmoortel-Van Der Aa Syndrome	HVDAS Mrd28 Adnp Syndrome Adnp-Related Syndromic Intellectual Disability-Autism Spectrum Disorder Mental Retardation, Autosomal Dominant 28 Adnp-Related Multiple Congenital Anomalies - Intellectual Disability - Autism Spectrum Disorder Mental Retardation, Autosomal Dominant 28, Formerly Mrd28, Formerly Autosomal Dominant Mental Retardation 28 Adnp-Related Intellectual Disability And Autism Spectrum Disorder Adnp-Related Multiple Congenital Anomalies-Intellectual Disability-Autism Spectrum Disorder
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08139	MAPRE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20568	Mapre3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27077	Mapre3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAPRE3	VGNC	VGNC:31234
Macaca mulatta	MAPRE3	VGNC	VGNC:74657
Felis catus	MAPRE3	VGNC	VGNC:68181
Mus musculus	MAPRE3	MGD	MGI:2140967
Rattus norvegicus	MAPRE3	RGD	RGD:1359297
Canis familiaris	MAPRE3	VGNC	VGNC:43011
Others	MAPRE3	NCBI