2. Gene
  3. Malt1 - MALT1 paracaspase Gene

Malt1 - MALT1 paracaspase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pcasp1; A630046N12; D430033E09Rik

Gene ID: 240354 | Gene type: protein coding

About Malt1

Chromosome 18: 65,564,009-65,612,138 forward strand.GRCm39:CM001011.3

This gene has 13 transcripts (splice variants), 197 orthologues and is associated with 14 phenotypes. Ubiquitous expression in spleen adult (RPKM 11.3), mammary gland adult (RPKM 4.9) and 27 other tissues.

Summary

Enables protease binding activity. Involved in lipopolysaccharide-mediated signaling pathway; positive regulation of immune response; and proteolysis. Acts upstream of or within several processes, including B-1 B cell differentiation; cellular response to lipopolysaccharide; and positive regulation of NF-kappaB transcription factor activity. Located in cytosol. Part of polkadots. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]

Malt1 Products(2)

mRNA Protein Name
NM_001365019.1 NP_001351948.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 2
NM_172833.3 NP_766421.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1

Malt1 Protein Structure

Death_MALT1

Death_MALT1: cd08783 (35 - 131)

Ig_3

Ig_3: pfam13927 (129 - 199)

Ig

Ig: cd00096 (149 - 153)

Ig

Ig: cd00096 (162 - 166)

Ig

Ig: cd00096 (178 - 182)

Ig

Ig: cd00096 (192 - 197)

Ig_3

Ig_3: pfam13927 (236 - 302)

Ig

Ig: cd00096 (252 - 256)

Ig

Ig: cd00096 (265 - 269)

Ig

Ig: cd00096 (295 - 300)

Ig

Ig: cd00096 (309 - 312)

Peptidase_C14

Peptidase_C14: pfam00656 (339 - 549)

MALT1_Ig

MALT1_Ig: pfam18703 (579 - 715)

  • 0
  • 200
  • 400
  • 600
  • 821 a.a.
Protein Preferred Names Protein Names

mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

mucosa associated lymphoid tissue lymphoma translocation gene 1

paracaspase-1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-139399 Safimaltib Inhibitor 99.89% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12276 MALT1 inhibitor MI-2 Inhibitor 99.95% Unkown
HY-115466 MLT-748 Inhibitor 99.90% Unkown
HY-121282 Mepazine Inhibitor 99.91% Unkown
HY-121282A Mepazine hydrochloride Inhibitor 99.94% Unkown
HY-134820 MLT-943 Inhibitor 99.77% Unkown
HY-142648 MLT-985 Inhibitor 99.34% Unkown
HY-P1407 Z-VRPR-FMK TFA Inhibitor 95.92% Unkown
HY-131902 MLT-231 Inhibitor 99.55% Unkown
HY-150232 MALT1-IN-11 Inhibitor / Unkown
HY-160698 SGR-1505 Inhibitor / Unkown
HY-124587 MLT-747 Inhibitor 99.56% Unkown
HY-143427 MALT1-IN-9 Inhibitor / Unkown
HY-120231 Z-VRPR-FMK Inhibitor / Unkown
HY-143423 MALT1-IN-5 Inhibitor / Unkown
HY-143425A (R)-MALT1-IN-7 Inhibitor / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-142648A (R)-MLT-985 Inhibitor / Unkown
HY-162268 MALT1-IN-13 Inhibitor / Unkown
HY-148249 NVS-MALT1 Inhibitor / Unkown
HY-143423A (S)-MALT1-IN-5 Inhibitor / Unkown
HY-P4544 Val-Arg-Pro-DL-Arg-Fluoromethylketone Inhibitor / Unkown
HY-143426 MALT1-IN-8 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-143424 MALT1-IN-6 Inhibitor / Unkown
HY-151805 RGT-068A Inhibitor / Unkown
HY-143425 MALT1-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Malt1 NCBI NCBI:10892