Ngfr - nerve growth factor receptor Gene

Also Known as p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24596

Summary

Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TrkA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of neuron death; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; portal hypertension; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ngfr Products (1)

mRNA Protein Name
NM_012610.2 NP_036742.2 tumor necrosis factor receptor superfamily member 16 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
19334058 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11756426 RGD
enables nerve growth factor binding IDA
IDA: Inferred from direct assay
3027580 RGD
enables neurotrophin TRKA receptor binding IPI
IPI: Inferred from physical interaction
9753156 RGD
enables neurotrophin binding IPI
IPI: Inferred from physical interaction
18596692 RGD
enables preprotein binding IPI
IPI: Inferred from physical interaction
20036257 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10485890 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23613963 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
19457114 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
23920372 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23920372 RGD
involved in negative regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
22548193 RGD
involved in negative regulation of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
19457114 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11438587 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
18786176 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12929129 RGD
involved in positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
18786176 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21539892 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
23114219 RGD
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
12424382 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
23940017 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
23940017 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
22292018 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
19457114 RGD
involved in positive regulation of synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
18256260 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
18256260 RGD
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19457114 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9267539 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21084570 RGD
involved in skeletal muscle cell differentiation IEP
IEP: Inferred from expression pattern
16723531 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
1315318 RGD
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated endocytic vesicle IDA
IDA: Inferred from direct assay
17897318 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
9521535 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9521535 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
22138126 RGD
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
20433604 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
9521535 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
9521535 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9767155 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20433604 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 16

  • NGF receptor

  • gp80-LNGFR

  • low affinity nerve growth factor receptor

  • low affinity neurotrophin receptor p75NTR

  • nerve growth factor receptor (TNFR superfamily, member 16)

  • nerve growth factor receptor, fast

  • p75 ICD

Ngfr Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ngfr P07174 NGF Homo sapiens P01138
X-Ray Diffraction
15131306
Intra
Ngfr P07174 Ngf Mus musculus P01139
Solution Sedimentation
18596692
Cross
Ngfr P07174 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
10514511
Cross
Ngfr P07174 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
10514511
Intra
Ngfr P07174 Ngfr Rattus norvegicus P07174
Crosslink
11756426
Intra
Ngfr P07174 Ngfr Rattus norvegicus P07174
Solution Sedimentation
18596692
Cross
Ngfr P07174 TRAF4 Homo sapiens Q9BUZ4
Anti Tag CoIP
10514511
Cross
Ngfr P07174 TRAF2 Homo sapiens Q12933
Pull Down
10514511
Cross
Ngfr P07174 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
21541365
Cross
Ngfr P07174 P05067-PRO_0000000093 Homo sapiens P05067-PRO_0000000093
Anti Bait CoIP
11756426
Intra
Ngfr P07174 Ntrk1 Rattus norvegicus P35739
Anti Bait CoIP
19549834
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111163 NSC49652 Inducer 98.74% Unkown
HY-RS09278 NGFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17166 Ngfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23616 Ngfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ngfr NCBI NCBI:4804