Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Mus musculus

Also known as CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik

Gene ID: 257632 | Gene type: protein coding

About Nod2

Chromosome 8: 89,373,943-89,415,102 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 52 phenotypes. Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues.

Summary

Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Nod2 Products(1)

mRNA	Protein	Name
NM_145857.2	NP_665856.2	nucleotide-binding oligomerization domain-containing protein 2

Nod2 Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

0
200
400
600
800
1013 a.a.

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 2

caspase recruitment domain family, member 15

caspase recruitment domain-containing protein 15

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13682	Mifamurtide	≥99.0%	Unkown
HY-13682B	Mifamurtide sodium	≥98.0%	Unkown
HY-13682C	Mifamurtide TFA	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nod2	NCBI	NCBI:64127

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