Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Also Known as CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 257632

About Nod2

Chromosome 8: 89,373,943-89,415,102 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 52 phenotypes. Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues.

Summary

Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Nod2 Products (1)

mRNA	Protein	Name
NM_145857.2	NP_665856.2	nucleotide-binding oligomerization domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables muramyl dipeptide binding	IDA IDA: Inferred from direct assay	18167348	MGI
enables muramyl dipeptide binding	IMP IMP: Inferred from mutant phenotype	25429073	MGI
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	18261938	MGI
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	22033934	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17187069	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of JNK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within activation of immune response	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within cellular response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	16949315	MGI
acts upstream of or within defense response to Gram-positive bacterium	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	15692051	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	15692052	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	19139201	MGI
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	21421666	MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within innate immune response in mucosa	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of interleukin-12 production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	14560001	MGI
acts upstream of interleukin-18 production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	19139201	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of interleukin-6 production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	15692051	MGI
involved in intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	31919280	MGI
acts upstream of macrophage cytokine production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	14560001	MGI
acts upstream of or within macrophage inflammatory protein-1 alpha production	IMP IMP: Inferred from mutant phenotype	19139201	MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within negative regulation of T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	16949315	MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	16949315	MGI
acts upstream of or within negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of or within negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within negative regulation of interleukin-18 production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	19139201	MGI
involved in negative regulation of macrophage apoptotic process	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within negative regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19139201	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	27007849	MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	23892723	MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	15692052	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of phagocytosis	IMP IMP: Inferred from mutant phenotype	19139201	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15220916	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of or within positive regulation of antibacterial peptide biosynthetic process	IDA IDA: Inferred from direct assay	18167348	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	19898471	MGI
acts upstream of or within positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP IMP: Inferred from mutant phenotype	15692051	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15692052	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	20008287	MGI
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18855982	MGI
acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	15692051	MGI
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of or within positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	21156799	MGI
acts upstream of or within positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	14560001	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	14560001	MGI
involved in positive regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	31919280	MGI
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	16203728	MGI
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	21156799	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	19139201	MGI
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	15620648	MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of or within positive regulation of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI
involved in regulation of appetite	IMP IMP: Inferred from mutant phenotype	35420957	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19218085	MGI
acts upstream of or within regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	19139201	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	27007849	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	15692051	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14560001	MGI
acts upstream of or within response to muramyl dipeptide	IDA IDA: Inferred from direct assay	15220916	MGI
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	35420957	MGI
acts upstream of or within response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	14560001	MGI
involved in response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	15692052	MGI
acts upstream of or within response to peptidoglycan	IDA IDA: Inferred from direct assay	15220916	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	35420957	MGI
acts upstream of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	15220916	MGI
acts upstream of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod2 Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

0
200
400
600
800
1013 a.a.

Protein Preferred Names	Protein Names
nucleotide-binding oligomerization domain-containing protein 2	caspase recruitment domain family, member 15 caspase recruitment domain-containing protein 15

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13682	Mifamurtide	99.58%	Unkown
HY-13682B	Mifamurtide sodium	99.92%	Unkown
HY-13682C	Mifamurtide TFA	98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.48%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-179009	NOD2 agonist 4	Agonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-176837	NOD2/TLR4 agonist-1	Agonist	/	Unkown
HY-175348	XB2M54	Inhibitor	/	Unkown
HY-101927	NOD1/2 antagonist-2	Antagonist	/	Unkown
HY-123925	CSLP43	Inhibitor	/	Unkown
HY-168158	NOD2 agonist 3	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nod2	NCBI	NCBI:64127