TES - testin LIM domain protein Gene

Homo sapiens

Also known as TESS; TESS-2

Gene ID: 26136 | Gene type: protein coding

About TES

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,210,539-116,258,783 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 3 paralogues. Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues.

Summary

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin Cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

TES Products(2)

mRNA	Protein	Name
NM_015641.4	NP_056456.1	testin isoform 1
NM_152829.3	NP_690042.1	testin isoform 2

TES Protein Structure

PET

LIM

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

testin

testis derived transcript (3 LIM domains)

Recombinant TES Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71353	Testin Protein, Human (His)	Q9UGI8 (M1-S421)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1532	Anabasine	Agonist	99.87%	Unkown
HY-111365	TES-1025	Inhibitor	98.12%	Unkown
HY-112619	TES-991	Inhibitor	99.65%	Unkown
HY-23430	TES		≥98.0%	Unkown
HY-151598	Pks13-TE inhibitor 2	Inhibitor	/	Unkown
HY-151599	Pks13-TE inhibitor 3	Inhibitor	/	Unkown
HY-156138A	CB-TE2A tetrahydrochloride		/	Unkown
HY-161046	PLK1-IN-8	Inhibitor	/	Unkown
HY-23430A	TES sodium		≥98.0%	Unkown
HY-23430S	TES-d15		/	Unkown
HY-D1392	Ag2Te QDs		/	Unkown
HY-P3571	[Ala2] Endothelin-3, human		/	Unkown
HY-RS14378	TES Human Pre-designed siRNA Set A		/	Unkown
HY-W014928	Anabasine hydrochloride	Agonist	/	Unkown
HY-W022973	Trinexapac-ethyl		/	Unkown
HY-155460	Pks13-TE inhibitor 4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TES	MGD	MGI:105081
Rattus norvegicus	TES	RGD	RGD:1566346
Felis catus	TES	VGNC	VGNC:66087
Bos taurus	TES	VGNC	VGNC:35752
Macaca mulatta	TES	VGNC	VGNC:78383
Canis familiaris	TES	VGNC	VGNC:47256
Macaca fascicularis	TES	NCBI
Canis lupus familiaris	TES	NCBI
Others	TES	NCBI

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