TES - testin LIM domain protein Gene

Also Known as TESS; TESS-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26136

About TES

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,210,539-116,258,783 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 3 paralogues. Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues.

Summary

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin Cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

TES Products (2)

mRNA Protein Name
NM_015641.4 NP_056456.1 testin isoform 1
NM_152829.3 NP_690042.1 testin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21278383 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
21278383 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11420696 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
21278383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TES Protein Structure

PET

PET: PET Domain (92 - 195)

LIM

LIM: LIM domain (236 - 296)

LIM

LIM: LIM domain (301 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

testin

  • testis derived transcript (3 LIM domains)

TES Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TES Q9UGI8 ACTL7A Homo sapiens Q9Y615
Far-WB
21278383
Intra
TES Q9UGI8 ACTL7A Homo sapiens Q9Y615
ITC
21278383
Intra
TES Q9UGI8 ACTL7A Homo sapiens Q9Y615
Pull Down
21278383
Intra
TES Q9UGI8 ENAH Homo sapiens Q8N8S7
Pull Down
21278383
Intra
TES Q9UGI8 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
TES Q9UGI8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
TES Q9UGI8 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TES Proteins

Cat. No. Product Name Accession Purity
HY-P71353 Testin Protein, Human (His) Q9UGI8 (M1-S421) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P11042 TE-8105 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W590989 GPhos Pd G6 98.50% Unkown
HY-111365 TES-1025 Inhibitor 98.39% Unkown
HY-B1532 Anabasine Agonist 99.02% Unkown
HY-23430 TES 99.91% Unkown
HY-112619 TES-991 99.65% Unkown
HY-179668 1x TE buffer, pH 8.0 / Unkown
HY-179668A 10x TE buffer, pH 8.0 / Unkown
HY-23430A TES sodium 98.0% Unkown
HY-W540232 4-Methoxyphenyl isothiocyanate Inhibitor 99.59% Unkown
HY-RS13599 SOX9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W101585 Isoamyl benzoate 99.99% Unkown
HY-173624 TE-11 Inhibitor 99.68% Unkown
HY-118147 ML356 Inhibitor / Unkown
HY-151598 Pks13-TE inhibitor 2 Inhibitor / Unkown
HY-151599 Pks13-TE inhibitor 3 Inhibitor / Unkown
HY-156138A CB-TE2A tetrahydrochloride / Unkown
HY-159518 ROS inducer 4 / Unkown
HY-161046 PLK1-IN-8 Inhibitor / Unkown
HY-172298 (R,S,S,S)-Orlistat Inhibitor / Unkown
HY-178962 Antitumor agent-207 / Unkown
HY-180793 PROTAC USP7 Degrader-2 Degrader / Unkown
HY-181157 T/E PPI-IN-1 Inhibitor / Unkown
HY-23430S TES-d15 / Unkown
HY-P3571 [Ala2] Endothelin-3, human / Unkown
HY-RS14378 TES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W014928 Anabasine hydrochloride Agonist / Unkown
HY-W022973 Trinexapac-ethyl Activator 98.06% Unkown
HY-126638 Marcfortine A / Unkown
HY-155460 Pks13-TE inhibitor 4 Inhibitor / Unkown
HY-42163S 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-Bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-(tosylmethyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol-d3 / Unkown
HY-RS16817 Tes Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23257 Tes Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TES MGD MGI:105081
Rattus norvegicus TES RGD RGD:1566346
Felis catus TES VGNC VGNC:66087
Bos taurus TES VGNC VGNC:35752
Macaca mulatta TES VGNC VGNC:78383
Canis familiaris TES VGNC VGNC:47256
Others TES NCBI