Aak1 - AP2 associated kinase 1 Gene

Also Known as Gm38495; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269774

About Aak1

Chromosome 6: 86,826,499-86,980,205 forward strand.GRCm39:CM000999.3

This gene has 9 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 38 phenotypes. Broad expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 15.4) and 24 other tissues.

Summary

Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein stabilization; and regulation of clathrin-dependent endocytosis. Predicted to act upstream of or within endocytosis and phosphorylation. Predicted to be located in cell leading edge and terminal bouton. Predicted to be part of clathrin complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Aak1 Products (5)

mRNA Protein Name
NM_001378654.1 NP_001365583.1 AP2-associated protein kinase 1 isoform 3
NM_001378655.1 NP_001365584.1 AP2-associated protein kinase 1 isoform 4
NM_177762.7 NP_808430.2 AP2-associated protein kinase 1 isoform 2
NM_001040106.3 NP_001035195.1 AP2-associated protein kinase 1 isoform 1
NM_001378652.1 NP_001365581.1 AP2-associated protein kinase 1 isoform 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in presynaptic endocytosis IDA
IDA: Inferred from direct assay
33376223 MGI
involved in presynaptic endocytosis IMP
IMP: Inferred from mutant phenotype
33376223 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aak1 Protein Structure

STKc_NAK_like

STKc_NAK_like: cd14037 (41 - 315)

PHA03378

PHA03378: cl33729 (295 - 428)

BMP2K_C

BMP2K_C: cl21131 (909 - 1121)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1127 a.a.
Protein Preferred Names Protein Names

AP2-associated protein kinase 1

AP2 associated kinase 1

  • adaptor-associated kinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-134829 BMS-986176 98.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-123940 SGC-AAK1-1 98.47% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171770 dAurAB5 Inhibitor 99.03% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-115868 BMS-911172 99.49% Unkown
HY-135871 BMT-124110 99.15% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149054 GSK-3β inhibitor 13 Inhibitor 99.74% Unkown
HY-147083 SGC-AAK1-1N Inhibitor 97.9% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-117453 BMS-901715 / Unkown
HY-120179A LP-922761 hydrate 98.0% Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-176705 AAK1-IN-9 Inhibitor / Unkown
HY-162388 TIM-098a Inhibitor / Unkown
HY-145838 AAK1-IN-4 / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-144301 AAK1-IN-2 / Unkown
HY-144302A AAK1-IN-3 TFA / Unkown
HY-185187 AAK1-IN-12 Inhibitor / Unkown
HY-176706 AAK1-IN-10 Inhibitor / Unkown
HY-144302 AAK1-IN-3 / Unkown
HY-101290 BMT-090605 Inhibitor 98.27% Unkown
HY-159931 HW161023 Inhibitor / Unkown
HY-145839 AAK1-IN-5 / Unkown
HY-144301A AAK1-IN-2 TFA / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-174213 AAK1-IN-7 Inhibitor / Unkown
HY-175536 AAK1-IN-11 Inhibitor / Unkown
HY-174214 AAK1-IN-8 Inhibitor / Unkown
HY-159879 AAK1-IN-6 Inhibitor / Unkown
HY-120092 BMT-046091 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aak1 NCBI NCBI:22848