Trem2 - triggering receptor expressed on myeloid cells 2 Gene

Also Known as Trem2-Mia; Trem2-Mib

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301227

Summary

Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2). [provided by Alliance of Genome Resources, Apr 2022]

Trem2 Products (1)

mRNA Protein Name
NM_001106884.1 NP_001100354.1 triggering receptor expressed on myeloid cells 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
31900229 RGD
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
31900229 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

triggering receptor expressed on myeloid cells 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10227 Bortezomib 99.97% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W017540 Cyclocreatine Activator 99.78% Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990043 Iluzanebart 98.63% Phase 2
HY-P991734 VHB937 99.9% Phase 2
HY-P990651 PY314 Inhibitor 96.35% Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10136 IA9 Inhibitor 97.24% Unkown
HY-160421 TREM2-IN-1 Inducer 99.34% Unkown
HY-175510 TREM2 agonist-5 Agonist 99.61% Unkown
HY-P10136A IA9 TFA Inhibitor 98.90% Unkown
HY-174369 TREM2 agonist-3 99.39% Unkown
HY-174378 TREM2 agonist-4 Inhibitor 99.81% Unkown
HY-182702 As48 97.52% Unkown
HY-P991754 Anti-Mouse TREM2 Antibody (178) 98.92% Unkown
HY-RS16526 Trem2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10227S Bortezomib-d8 98.0% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-178324 T2M-010 / Unkown
HY-RS15003 TREM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182756 TREM2 modulator-1 Modulator / Unkown
HY-10227G Bortezomib (GMP) / Unkown
HY-164641 GPR34 agonist 1 Agonist / Unkown
HY-P10220 NOTA-COG1410 Ligand / Unkown
HY-W017540S Cyclocreatine-13C3 / Unkown
HY-N9164 Hecubine / Unkown
HY-RS22957 Trem2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991220 AL002 Agonist 98.01% Unkown
HY-P991621 EOS006215 Inhibitor 98.47% Unkown
HY-P991442 DNL-919 (Human IgG1) Agonist 96.17% Unkown
HY-P991174 Anti-TREM2 Antibody (AL2p-58) Inhibitor 97.43% Unkown
HY-P992118 Lifonebart Inhibitor 99.9% Unkown
HY-P992513 Anti-Mouse TREM2 Antibody (4D9) Inhibitor 97.42% Unkown
HY-P991905 AL044 97.39% Unkown
HY-P992516 DNL-919 (ATV) Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trem2 NCBI NCBI:54209