Traf6 - TNF receptor associated factor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311245

Summary

Predicted to enable several functions, including enzyme binding activity; tumor necrosis factor receptor binding activity; and ubiquitin protein Ligase activity. Involved in JNK cascade; interleukin-1-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Part of protein-containing complex. Orthologous to human TRAF6 (TNF Receptor associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Traf6 Products (1)

mRNA Protein Name
NM_001107754.2 NP_001101224.1 TNF receptor-associated factor 6

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
27249171 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
27249171 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20967881 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
28973854 RGD
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
28973854 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
27538408 RGD
involved in synapse assembly EXP
EXP: Inferred from Experiment
33363141 RGD
involved in synapse assembly IDA
IDA: Inferred from direct assay
33363141 RGD
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
33363141 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
33363141 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28973854 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
28973854 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20967881 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNF receptor-associated factor 6

  • E3 ubiquitin-protein ligase TRAF6

  • RING-type E3 ubiquitin transferase TRAF6

  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1829A Dexamethasone phosphate disodium 99.94% Yes
HY-B1829AR Dexamethasone phosphate disodium (Standard) 99.88% Unkown

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120934 C25-140 Inhibitor 99.92% Unkown
HY-110247 TRAF-STOP inhibitor 6877002 Inhibitor 99.67% Unkown
HY-N0481 Roburic acid 99.93% Unkown
HY-N1431 Tabersonine 98.13% Unkown
HY-N0026 2'-Acetylacteoside Inhibitor 99.73% Unkown
HY-N0320 Salvianolic acid D 95.15% Unkown
HY-142026 Vitisin A 96% Unkown
HY-P3709A TRAF6 peptide TFA Inhibitor 98.20% Unkown
HY-W013636C 2-Ketoglutaric acid potassium Inhibitor 98.0% Unkown
HY-125025 SMI 6860766 Inhibitor / Unkown
HY-164670 D228 Inhibitor 99.77% Unkown
HY-NP134 Flagellin from S. typhimurium 95% Unkown
HY-P3709 TRAF6 peptide Inhibitor / Unkown
HY-B1829 Dexamethasone phosphate 98.89% Yes
HY-RS23098 Traf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-155801 CRX 527 / Unkown
HY-176220 GPX4-AUTAC / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-P11001 RANK-derived TRAF6 inhibitor Inhibitor / Unkown
HY-P11002 PTD Control / Unkown
HY-P3708 TRAF6 control peptide Control / Unkown
HY-RS14975 TRAF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174520 Human TLR8 mRNA / Unkown
HY-B1829R Dexamethasone phosphate (Standard) / Unkown
HY-N1431A Tabersonine hydrochloride 98.55% Unkown
HY-RS16663 Traf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf6 NCBI NCBI:7189