Traf6 - TNF receptor associated factor 6 Gene

Rattus norvegicus

Gene ID: 311245 | Gene type: protein coding

About Traf6

Summary

Predicted to enable several functions, including enzyme binding activity; tumor necrosis factor receptor binding activity; and ubiquitin protein Ligase activity. Involved in JNK cascade; interleukin-1-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Part of protein-containing complex. Orthologous to human TRAF6 (TNF Receptor associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Traf6 Products(1)

mRNA	Protein	Name
NM_001107754.2	NP_001101224.1	TNF receptor-associated factor 6

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	27249171	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	27249171	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20967881	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in regulation protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	28973854	RGD
involved in regulation protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	28973854	RGD
involved in regulation protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	28973854	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	27538408	RGD
involved in synapse assembly	EXP EXP: Inferred from Experiment	33363141	RGD
involved in synapse assembly	IDA IDA: Inferred from direct assay	33363141	RGD
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	33363141	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	33363141	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28973854	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28973854	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	28973854	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20967881	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNF receptor-associated factor 6

E3 ubiquitin-protein ligase TRAF6	RING-type E3 ubiquitin transferase TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Related Agents

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120934	C25-140	Inhibitor	99.92%	Unkown
HY-N0481	Roburic acid		99.93%	Unkown
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	Unkown
HY-N1431	Tabersonine		98.13%	Unkown
HY-N0026	2'-Acetylacteoside	Inhibitor	99.73%	Unkown
HY-N0320	Salvianolic acid D		95.28%	Unkown
HY-P3709A	TRAF6 peptide TFA	Inhibitor	98.20%	Unkown
HY-W013636C	2-Ketoglutaric acid potassium	Inhibitor	98.0%	Unkown
HY-125025	SMI 6860766	Inhibitor	/	Unkown
HY-142026	Vitisin A		96%	Unkown
HY-164670	D228	Inhibitor	99.77%	Unkown
HY-NP134	Flagellin from S. typhimurium		95%	Unkown
HY-P3709	TRAF6 peptide	Inhibitor	/	Unkown
HY-RS23098	Traf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-155801	CRX 527		/	Unkown
HY-176220	GPX4-AUTAC		/	Unkown
HY-P11001	RANK-derived TRAF6 inhibitor	Inhibitor	/	Unkown
HY-P11002	PTD	Control	/	Unkown
HY-P3708	TRAF6 control peptide	Control	/	Unkown
HY-RS14975	TRAF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174520	Human TLR8 mRNA		/	Unkown
HY-N1431A	Tabersonine hydrochloride		98.55%	Unkown
HY-RS16663	Traf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf6	NCBI	NCBI:7189

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