Prmt5 - protein arginine methyltransferase 5 Gene

Also Known as Skb1; Hrmt1l5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 364382

About Prmt5

Primary_assembly 15: 27,968,910-27,978,296 reverse strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 9 phenotypes. Biased expression in Kidney (RPKM 128.5), Brain (RPKM 19.8) and 9 other tissues.

Summary

Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; positive regulation of oligodendrocyte differentiation; and regulation of ERK1 and ERK2 cascade. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]

Prmt5 Products (1)

mRNA Protein Name
NM_001108867.2 NP_001102337.2 protein arginine N-methyltransferase 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15837430 RGD
Biological Process GO Annotation Evidence References Source
involved in liver regeneration IEP
IEP: Inferred from expression pattern
15837430 RGD
involved in negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
21917714 RGD
involved in negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
22041901 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22041901 RGD
involved in protein methylation IMP
IMP: Inferred from mutant phenotype
21917714 RGD
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21917714 RGD
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22041901 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
12101096 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt5 Protein Structure

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 289)

PRMT5

PRMT5: pfam05185 (294 - 463)

PRMT5_C

PRMT5_C: pfam17286 (467 - 634)

  • 0
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  • 200
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  • 400
  • 500
  • 600
  • 637 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 5

  • HMT1 hnRNP methyltransferase-like 5

  • SKB1 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-139611 Navlimetostat Inhibitor 99.28% Phase 3
HY-101563 GSK3326595 Inhibitor 99.83% Phase 2
HY-148419 Ralometostat Inhibitor 99.90% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.84% Phase 1
HY-141876 PRT543 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12727 EPZ015666 Inhibitor 99.86% Unkown
HY-100235 GSK591 Inhibitor 99.91% Unkown
HY-107777 LLY-283 Inhibitor 98.93% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-100025A HLCL-61 hydrochloride Inhibitor 99.87% Unkown
HY-132309 BRD0639 Inhibitor 98.04% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-139611C Navlimetostat hydrochloride Inhibitor 99.61% Unkown
HY-148674 AM-9747 Inhibitor 99.76% Unkown
HY-109963 PR5-LL-CM01 Inhibitor 98.37% Unkown
HY-Q36691 PRMT5-IN-30 Inhibitor 99.35% Unkown
HY-139611B (S)-Navlimetostat Inhibitor 98.15% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-120137 CMP-5 Inhibitor 99.61% Unkown
HY-158143 AZD3470 Inhibitor 99.74% Unkown
HY-128579 DW14800 Inhibitor 99.12% Unkown
HY-126256A PRMT5-IN-1 hydrochloride Inhibitor 99.51% Unkown
HY-W072962 WX2-43 Inhibitor 99.49% Unkown
HY-111213 PRMT5-IN-20 Inhibitor 99.20% Unkown
HY-126256 PRMT5-IN-1 Inhibitor / Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-182820 YZ-836P / Unkown
HY-134883 PRMT5-IN-4 Inhibitor 99.0% Unkown
HY-182892 MC4491 Inhibitor / Unkown
HY-169708 PRMT5-IN-49 Inhibitor / Unkown
HY-173092 PRMT5 ligand 1 Ligand / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-176534 PRMT5-IN-52 Inhibitor / Unkown
HY-163593 PRMT5-IN-44 Inhibitor / Unkown
HY-111213A PRMT5-IN-20 hydrochloride Ligand / Unkown
HY-178028 PRMT5-IN-53 Inhibitor / Unkown
HY-150081 PRMT5-IN-21 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-168842 PRMT5-IN-47 Inhibitor / Unkown
HY-163587 PRMT5-IN-39-d3 Inhibitor / Unkown
HY-163799 PRMT5-MTA-IN-1 Inhibitor / Unkown
HY-P3822 PRMT5-IN-23 Inhibitor / Unkown
HY-180356 PRMT5-IN-54 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-132937 PRMT5-IN-9 Inhibitor / Unkown
HY-153421 PRMT5-IN-28 Inhibitor / Unkown
HY-176702 PRMT5-MTA-IN-5 Inhibitor / Unkown
HY-176701 PRMT5-MTA-IN-4 Inhibitor / Unkown
HY-163592 PRMT5-IN-43 Inhibitor / Unkown
HY-181522 PRMT5 ligand 3 Ligand / Unkown
HY-183951 TNG456 Inhibitor / Unkown
HY-184434 PRMT5-IN-57 Inhibitor / Unkown
HY-168263 PRMT5-IN-45 Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-163591 PRMT5-IN-36-d3 Inhibitor / Unkown
HY-181521 RAPRMT5 Degrader / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt5 NCBI NCBI:10419