STS - steroid sulfatase Gene

Also Known as ES; ASC; XLI; ARSC; SSDD; ARSC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 412

About STS

Cytogenetic location: Xp22.31 Genomic coordinates (GRCh38): X:7,147,290-7,354,641 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues, 16 paralogues and is associated with 4 phenotypes. Broad expression in placenta (RPKM 15.1), fat (RPKM 11.7) and 22 other tissues.

Summary

This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and Cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

STS Products (6)

mRNA	Protein	Name
NM_000351.7	NP_000342.3	steryl-sulfatase isoform 1 precursor
NM_001320750.3	NP_001307679.1	steryl-sulfatase isoform 2 precursor
NM_001320751.2	NP_001307680.1	steryl-sulfatase isoform 2 precursor
NM_001320752.2	NP_001307681.2	steryl-sulfatase isoform 1 precursor
NM_001320753.2	NP_001307682.1	steryl-sulfatase isoform 1 precursor
NM_001320754.2	NP_001307683.1	steryl-sulfatase isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sulfuric ester hydrolase activity	IDA IDA: Inferred from direct assay	15962010	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STS Protein Structure

Sulfatase

Sulfatase_C

0
100
200
300
400
500
583 a.a.

Protein Preferred Names	Protein Names
steryl-sulfatase	arylsulfatase C

Related Diseases

Diseases	Alias
Ichthyosis, X-Linked	X-Linked Ichthyosis Steroid Sulfatase Deficiency Placental Steroid Sulfatase Deficiency Steroid Sulfatase Deficiency Disease XLI Sts Deficiency Ssdd X-Linked Recessive Ichthyosis X-Linked Ichthyosis With Steryl-Sulphatase Deficiency X-Linked Placental Steryl-Sulphatase Deficiency Ssd X Linked Ichthyosis Recessive X-Linked Ichthyosis Rxli Syndromic Recessive X-Linked Ichthyosis Recessive X-Linked Ichthyosis With Extracutaneous Manifestations Syndromic Rxli X-Linked Ichthyosis Syndrome IXL Ichthyosis X-Linked Sex-Linked Ichthyosis X-Linked Ichthyosis With Steryl-Sulfatase Deficiency
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Multiple Sulfatase Deficiency	Mucosulfatidosis MSD Sulfatidosis, Juvenile, Austin Type Multiple Sulfatase Deficiency Disease Juvenile Sulfatidosis, Austin Type Juvenile Sulfatidosis Sulfatidosis Juvenile, Austin Type Austin Syndrome Sulfatidosis Juvenile Austin Type Sulfatase Deficiency, Multiple
Chondrodysplasia Punctata Syndrome	Chondrodysplasia Punctata Chondrodysplasia Punctata Congenita Toriello Higgins Miller Syndrome Chondrodysplasia Punctata, Toriello Type Toriello-Higgins-Miller Syndrome Cdp Chondrodysplasia Punctata, X-Linked Dominant Type Chondrodysplasia Punctata Group Dysplasia Punctata Epiphysis Dysplasia Punctata Dysplasia Epiphysealis Punctata Chondrodystrophy Of Punctata
Smith-Lemli-Opitz Syndrome	SLOS Rsh Syndrome 7-Dehydrocholesterol Reductase Deficiency Slo Syndrome Rutledge Lethal Multiple Congenital Anomaly Syndrome Lethal Acrodysgenital Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung Smith-Opitz-Inborn Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung Smith Lemli Opitz Syndrome Smith-Lemli-Opitz Syndrome, Type Ii
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Chondrodysplasia Punctata 2, X-Linked Dominant	CDPX2 Happle Syndrome Chondrodysplasia Punctata, X-Linked Dominant Cdpxd Cpxd Conradi-Hunermann Syndrome Conradi-Hunermann-Happle Syndrome Chondrodysplasia Punctata 2 X-Linked Dominant X-Linked Dominant Chondrodysplasia Punctata 2 Conrad Hunermann Happle Syndrome Conradi Hunermann Syndrome Chh Chondrodysplasia Punctata, Type 2, X-Linked Dominant Chondrodysplasia Punctata, X-Linked Dominant Type Chondrodysplasia Punctata
Metachromatic Leukodystrophy	Arylsulfatase A Deficiency MLD Arsa Deficiency Sulfatide Lipidosis Metachromatic Leukoencephalopathy Cerebral Sclerosis, Diffuse, Metachromatic Form Cerebroside Sulfatase Deficiency Leukodystrophy, Metachromatic Pseudoarylsulfatase A Deficiency Leukodystrophy Metachromatic Sulfatidosis Metachromatic Leukodystrophy, Late Infantile Metachromatic Leukodystrophy Variant Deficiency Of Cerebroside-Sulfatase Scholz Cerebral Sclerosis Sulfatide Lipoidosis Cerebral Sclerosis Diffuse Metachromatic Form Arylsulfatase A Deficiency Disease Cerebroside Sulphatase Deficiency Disease Greenfield Disease Metachromatic Leukodystrophy, Adult Metachromatic Leukodystrophy, Juvenile Leukodystrophy Metachromatic Adult Leukodystrophy Metachromatic Juvenile Leukodystrophy Metachromatic Late Infantile Metachromatic Leukodystrophy, Adult Type Metachromatic Leukodystrophy, Juvenile Type Metachromatic Leukodystrophy, Infant Greenfield'S Disease
Ocular Albinism	Albinism, Ocular Oa Xloa Albinism Ocular
Alopecia, Androgenetic, 1	Androgenetic Alopecia Androgenic Alopecia AGA1 Aga Female Pattern Baldness Male Pattern Alopecia Male Pattern Baldness Pattern Baldness Alopecia, Androgenetic Alopecia Androgenetic Female Pattern Alopecia
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Corneal Dystrophy, Thiel-Behnke Type	Thiel-Behnke Corneal Dystrophy Tbcd CDTB Cdb2 Corneal Dystrophy Of Bowman Layer Type Ii Anterior Limiting Membrane Dystrophy Type Ii Waardenburg-Jonker Corneal Dystrophy Corneal Dystrophy Of Bowman Layer, Type Ii Corneal Dystrophy, Honeycomb-Shaped Corneal Dystrophy Honeycomb-Shaped Corneal Dystrophy Thiel Behnke Type Corneal Dystrophy Honeycomb Shaped Corneal Dystrophy Of The Bowman Layer Type 2 Thiel Behnke Corneal Dystrophy Anterior Limiting Membrane Dystrophy Type 2 Corneal Dystrophy Of Bowman Layer Type 2 Curly Fiber Corneal Dystrophy Honeycomb Corneal Dystrophy Honeycomb-Shaped Corneal Dystrophy Dystrophy, Corneal, Thiel-Behnke Type
Dysostosis	Dysostoses
Cri-Du-Chat Syndrome	5p Deletion Syndrome 5p Partial Monosomy Syndrome Monosomy 5p Cat Cry Syndrome Chromosome 5p Deletion Syndrome Cri Du Chat Syndrome 5p- Syndrome 5p Minus Syndrome Chromosome 5p- Syndrome Chromosome 5 Short Arm Deletion Syndrome Chromosome 5p Deletion Deletion 5p Cri Du Chat 5p Partial Deletion Syndrome Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0084	Dienogest	Agonist	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15141	Staurosporine		99.77%	Unkown
HY-W062700	STS-E412	Activator	99.72%	Unkown
HY-15141G	Staurosporine (GMP)	Inhibitor	/	Unkown
HY-175869	Ferroptosis-IN-22	Inhibitor	99.97%	Unkown
HY-14585	Estrone O-sulfamate	Inhibitor	99.99%	Unkown
HY-112944A	CMP-SiaNAz sodium	Substrate	93.0%	Unkown
HY-123773	SR-16157		/	Unkown
HY-123868	KW-2581	Inhibitor	/	Unkown
HY-150542	Steroid sulfatase-IN-2	Inhibitor	/	Unkown
HY-150543	Steroid sulfatase-IN-3	Inhibitor	/	Unkown
HY-151200	Steroid sulfatase-IN-4	Inhibitor	/	Unkown
HY-151201	Steroid sulfatase/17β-HSD1-IN-3	Inhibitor	/	Unkown
HY-151202	Steroid sulfatase/17β-HSD1-IN-4	Inhibitor	/	Unkown
HY-155010	Steroid sulfatase/17β-HSD1-IN-5	Inhibitor	/	Unkown
HY-155233	Steroid sulfatase-IN-5	Inhibitor	/	Unkown
HY-155234	Steroid sulfatase-IN-6	Inhibitor	/	Unkown
HY-155235	Steroid sulfatase-IN-7	Inhibitor	/	Unkown
HY-156511	ETC-168	Inhibitor	/	Unkown
HY-156902	Steroid sulfatase-IN-8	Inhibitor	/	Unkown
HY-172605	Steroid sulfatase-IN-9	Inhibitor	/	Unkown
HY-B0084S	Dienogest-d4		/	Unkown
HY-B0084S1	Dienogest-d5		/	Unkown
HY-B0084S2	Dienogest-d6		99.92%	Unkown
HY-B0084S4	Dienogest-13C,15N,d4	Agonist	/	Unkown
HY-RS13969	STS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181408	Steroid sulfatase-IN-11	Inhibitor	/	Unkown
HY-B0084S3	Dienogest-13C2,15N	Agonist	/	Unkown
HY-RS16525	Sts Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22956	Sts Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STS	RGD	RGD:3783
Canis familiaris	STS	VGNC	VGNC:54604
Felis catus	STS	VGNC	VGNC:97650
Bos taurus	STS	VGNC	VGNC:49976
Macaca mulatta	STS	VGNC	VGNC:81590
Mus musculus	STS	MGD	MGI:98438
Others	STS	NCBI