FOXO4 - forkhead box O4 Gene

Homo sapiens

Also known as AFX; AFX1; MLLT7

Gene ID: 4303 | Gene type: protein coding

About FOXO4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,095,851-71,103,532 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues, 42 paralogues and is associated with 52 phenotypes. Broad expression in placenta (RPKM 74.9), testis (RPKM 15.0) and 21 other tissues.

Summary

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

FOXO4 Products(2)

mRNA	Protein	Name
NM_001170931.2	NP_001164402.1	forkhead box protein O4 isoform 2
NM_005938.4	NP_005929.2	forkhead box protein O4 isoform 1

FOXO4 Protein Structure

Forkhead

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

forkhead box protein O4

fork head domain transcription factor AFX1

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153347	JY-2	Inhibitor	99.75%	Unkown
HY-P4157	FOXO4-DRI		99.87%	Unkown
HY-P4157A	FOXO4-DRI acetate		/	Unkown
HY-RS05071	FOXO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXO4	VGNC	VGNC:40964
Macaca mulatta	FOXO4	VGNC	VGNC:72712
Rattus norvegicus	FOXO4	RGD	RGD:1561201
Bos taurus	FOXO4	VGNC	VGNC:29100
Mus musculus	FOXO4	MGD	MGI:1891915
Felis catus	FOXO4	VGNC	VGNC:68274

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