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OTUB1 - OTU deubiquitinase, ubiquitin aldehyde binding 1 Gene

Also Known as OTB1; OTU1; HSPC263

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55611

About OTUB1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,986,438-63,998,412 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues.

Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin Ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

OTUB1 Products (1)

mRNA	Protein	Name
NM_017670.3	NP_060140.2	ubiquitin thioesterase OTUB1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	18954305	GOA
enables deNEDDylase activity	IDA IDA: Inferred from direct assay	18954305	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16364312	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	19211026	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	20725033	GOA
enables ubiquitin-protein transferase inhibitor activity	IDA IDA: Inferred from direct assay	35927303	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20725033	GOA
involved in negative regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	20725033	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35927303	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	18954305	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	35927303	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUB1 Protein Structure

Peptidase_C65

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
ubiquitin thioesterase OTUB1	OTU domain, ubiquitin aldehyde binding 1

OTUB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OTUB1	Q96FW1	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	OTUB1	Q96FW1	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	OTUB1	Q96FW1	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	OTUB1	Q96FW1	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	OTUB1	Q96FW1	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	OTUB1	Q96FW1	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	PARK7	Homo sapiens	Q99497	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	OTUB1	Q96FW1	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	OTUB1	Q96FW1	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	32296183
Intra	OTUB1	Q96FW1	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	32296183
Intra	OTUB1	Q96FW1	UBE2E2	Homo sapiens	Q96LR5	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBE2E2	Homo sapiens	Q96LR5	Y2H Prey Pooling	32296183
Intra	OTUB1	Q96FW1	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	OTUB1	Q96FW1	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	TPP1	Homo sapiens	O14773	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	TPP1	Homo sapiens	O14773	Y2H Array	32814053
Intra	OTUB1	Q96FW1	TPP1	Homo sapiens	O14773	Y2H Pooling	32814053
Cross	OTUB1	Q96FW1	ypkA	Yersinia pestis	Q9RI12	Protein Kinase Assay	16364312
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Anti Tag CoIP	22124327
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Y2H Prey Pooling	32296183
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Y2H	19549727
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Anti Tag CoIP	19615732
Intra	OTUB1	Q96FW1	UBE2D2	Homo sapiens	P62837	Y2H Array	32296183
Intra	OTUB1	Q96FW1	UBE2D3	Homo sapiens	P61077	Anti Tag CoIP	22124327
Intra	OTUB1	Q96FW1	UBE2D3	Homo sapiens	P61077	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBE2D3	Homo sapiens	P61077	Validated Y2H	25416956
Intra	OTUB1	Q96FW1	UBE2D3	Homo sapiens	P61077	Y2H	19549727
Intra	OTUB1	Q96FW1	UBE2D3	Homo sapiens	P61077	Y2H Array	25416956
Intra	OTUB1	Q96FW1	UBE2E3	Homo sapiens	Q969T4	Y2H Array	32296183
Intra	OTUB1	Q96FW1	UBE2E3	Homo sapiens	Q969T4	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBE2E3	Homo sapiens	Q969T4	Y2H Prey Pooling	32296183
Intra	OTUB1	Q96FW1	UBE2E1	Homo sapiens	P51965	Anti Tag CoIP	33961781
Intra	OTUB1	Q96FW1	UBE2E1	Homo sapiens	P51965	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	OTUB1	Q96FW1	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	TP53	Homo sapiens	P04637	Anti Tag CoIP	22124327
Intra	OTUB1	Q96FW1	TP53	Homo sapiens	P04637	Pull Down	22124327
Intra	OTUB1	Q96FW1	TP53	Homo sapiens	P04637	Anti Bait CoIP	22124327
Intra	OTUB1	Q96FW1	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	22124327
Intra	OTUB1	Q96FW1	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	22124327
Intra	OTUB1	Q96FW1	MDM2	Homo sapiens	Q00987	Pull Down	22124327
Intra	OTUB1	Q96FW1	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	OTUB1	Q96FW1	BIRC2	Homo sapiens	Q13490	Anti Bait CoIP	23524849
Intra	OTUB1	Q96FW1	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	OTUB1	Q96FW1	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	OTUB1	Q96FW1	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	OTUB1	Q96FW1	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	OTUB1	Q96FW1	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	UBA1	Homo sapiens	P22314	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBA1	Homo sapiens	P22314	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	UBA1	Homo sapiens	P22314	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	UBA1	Homo sapiens	P22314	Y2H Array	32814053
Intra	OTUB1	Q96FW1	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	OTUB1	Q96FW1	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	HEXB	Homo sapiens	P07686	Y2H Array	32814053
Intra	OTUB1	Q96FW1	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	OTUB1	Q96FW1	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	OTUB1	Q96FW1	UBE2D1	Homo sapiens	P51668	Y2H Array	32296183
Intra	OTUB1	Q96FW1	UBE2D1	Homo sapiens	P51668	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	UBE2D1	Homo sapiens	P51668	Y2H Prey Pooling	32296183
Intra	OTUB1	Q96FW1	UBE2D1	Homo sapiens	P51668	Anti Tag CoIP	22124327
Intra	OTUB1	Q96FW1	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	OTUB1	Q96FW1	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	OTUB1	Q96FW1	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Prey Pooling	25416956
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	25416956
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	32296183
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	31515488
Intra	OTUB1	Q96FW1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Prey Pooling	32296183
Intra	OTUB1	Q96FW1	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	26752685
Intra	OTUB1	Q96FW1	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	OTUB1	Q96FW1	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	OTUB1	Q96FW1	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Cross	OTUB1	Q96FW1	ypkA	Yersinia enterocolitica	Q56921	Anti Tag CoIP	20553488

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OTUB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75952	OTUB1 Protein, Human (His)	Q96FW1-1 (M1-K271)	≥ 95%, as determined by reducing SDS-PAGE.

OTUB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81738	OTUB1 Antibody (YA1483)	WB, IP	Human, Mouse, Rat
HY-P81738A	OTUB1 Antibody (YA1483)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151563	OTUB1/USP8-IN-1	Inhibitor	98.31%	Unkown
HY-151563A	OTUB1/USP8-IN-1 TFA	Inhibitor	99.56%	Unkown
HY-143345	EN523	Ligand	99.22%	Unkown
HY-115878	NJH-2-057	Modulator	98.84%	Unkown
HY-144999	LEB-03-146		98.08%	Unkown
HY-143344	NJH-2-056	Modulator	98.31%	Unkown
HY-143340	LEB-03-145		/	Unkown
HY-143342	LEB-03-144		/	Unkown
HY-143343	LEB-03-153		/	Unkown
HY-162966	MS7829	Activator	/	Unkown
HY-162967	MS8588	Degrader	/	Unkown
HY-175934	MS5105	Ligand	/	Unkown
HY-182350	FXR DUBTAC modulator-1	Modulator	/	Unkown
HY-183724	MS8572	Ligand	/	Unkown
HY-183725	MS5128	Modulator	/	Unkown
HY-185122	MS6178	Activator	/	Unkown
HY-RS09869	OTUB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16735	Otub1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23172	Otub1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OTUB1	VGNC	VGNC:32491
Felis catus	OTUB1	VGNC	VGNC:63999
Mus musculus	OTUB1	MGD	MGI:2147616
Canis familiaris	OTUB1	VGNC	VGNC:49784
Rattus norvegicus	OTUB1	RGD	RGD:1311329
Others	OTUB1	NCBI