TNFRSF17 - TNF receptor superfamily member 17 Gene

Homo sapiens

Also known as BCM; BCMA; CD269; TNFRSF13A

Gene ID: 608 | Gene type: protein coding

About TNFRSF17

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,965,210-11,968,068 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 1 paralogue and is associated with 36 phenotypes. Biased expression in lymph node (RPKM 11.9), duodenum (RPKM 11.5) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

TNFRSF17 Products(1)

mRNA	Protein	Name
NM_001192.3	NP_001183.2	tumor necrosis factor receptor superfamily member 17

TNFRSF17 Protein Structure

BCMA-Tall_bind

0
100
184 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 17

B cell maturation antigen

Recombinant TNFRSF17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7132	BCMA/TNFRSF17 Protein, Human	Q02223 (A5-A54)	≥95%
HY-P7654	BCMA/TNFRSF17 Protein, Human (HEK293, Fc)	Q02223 (M1-A54)	≥95%
HY-P7655	BCMA/TNFRSF17 Protein, Human (P.pastoris, His)	Q02223 (M1-A54)	≥95%
HY-P70827	BCMA/TNFRSF17 Protein, Human (HEK293, mFc)	Q02223 (M1-A54)	≥95%
HY-P72342	BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q02223 (M1-A54)	≥95%
HY-P72847	BCMA/TNFRSF17 Protein, Human (HEK293, His)	Q02223 (M1-A54)	≥95%
HY-P72848	BCMA/TNFRSF17 Protein, Human (HEK293, His-Fc)	Q02223 (M1-A54)	≥95%
HY-P78070	BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi)	Q02223 (M1-A54)	≥95%
HY-P78071	BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi)	Q02223 (M1-A54)	≥95%
HY-P78388	BCMA/TNFRSF17 Protein, Human (HEK293, His-Avi)	Q02223 (M1-A54)	≥95%
HY-P78389	BCMA/TNFRSF17 Trimer Protein, Human (HEK293, His-Avi)	Q02223 (M1-A54)	≥95%
HY-P700663	BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi)	Q02223 (M1-A54)	≥95%

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Cardiomyopathy, Familial Hypertrophic, 12

Hypertrophic Cardiomyopathy 12	CMH12
Cardiomyopathy, Hypertrophic, 12	Cardiomyopathy Familial Hypertrophic 12
Cardiomyopathy, Familial Hypertrophic 12	Cardiomyopathy, Hypertrophic, Familial, Type 12

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Cardiomyopathy, Dilated, 2a

Dilated Cardiomyopathy 2a	CMD2A
Cardiomyopathy, Dilated, Autosomal Recessive	Cardiomyopathy, Congestive, Autosomal Recessive
Cardiomyopathy, Dilated 2a	Cardiomyopathy, Dilated, Type 2a
Autosomal Recessive Dilated Cardiomyopathy

Cardiomyopathy, Dilated, 1ff

Dilated Cardiomyopathy 1ff	CMD1FF
Cardiomyopathy, Dilated 1ff	Cardiomyopathy, Dilated, Type 1ff

Smoldering Myeloma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Retinitis Pigmentosa 90

RP90	Retinitis Pigmentosa, Type 90

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Anemia, Congenital Dyserythropoietic, Type Ib

CDAN1B	Congenital Dyserythropoietic Anemia Type Ib
Cda, Type Ib	Congenital Dyserythropoietic Anemia Type Type 1b
Dyserythropoietic Anemia, Congenital, Type Ib	Anemia, Congenital Dyserythropoietic, 1b
Cda Ib	Anemia, Dyserythropoietic, Congenital
Anemia, Dyserythropoietic, Congenital, Type Ib

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance	Mgus
Mgus - [Monoclonal Gammopathy Of Undetermined Significance]	Monoclonal Gammopathy Nos
Iga Gammopathy	Monoclonal Gammoglobulinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9980	Belantamab	Inhibitor	99.90%	Phase 3
HY-P9989	Linvoseltamab	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14807	TNFRSF17 Human Pre-designed siRNA Set A		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990095	Vonsetamig	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF17	MGD	MGI:1343050
Canis familiaris	TNFRSF17	VGNC	VGNC:47659
Macaca mulatta	TNFRSF17	VGNC	VGNC:78586
Bos taurus	TNFRSF17	VGNC	VGNC:106989
Rattus norvegicus	TNFRSF17	RGD	RGD:1304703
Macaca fascicularis	TNFRSF17	NCBI
Others	TNFRSF17	NCBI

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