CCL21 - C-C motif chemokine ligand 21 Gene

Also Known as ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6366

About CCL21

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,709,005-34,710,136 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 25 paralogues. Biased expression in lymph node (RPKM 1020.3), spleen (RPKM 170.8) and 2 other tissues.

Summary

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to Other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for Chemokine Receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

CCL21 Products (1)

mRNA	Protein	Name
NM_002989.4	NP_002980.1	C-C motif chemokine 21 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	15778365	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	23341447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14978162	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18308860	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	18308860	GOA
involved in dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	15778365	GOA
involved in establishment of T cell polarity	IDA IDA: Inferred from direct assay	12729902	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in mesangial cell-matrix adhesion	IDA IDA: Inferred from direct assay	15569314	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	15059845	GOA
involved in negative regulation of leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18308860	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	12729902	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15778365	GOA
acts upstream of or within positive regulation of T cell migration	IDA IDA: Inferred from direct assay	23620790	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	11242036	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	15569314	GOA
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	15569314	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	15569314	GOA
involved in positive regulation of myeloid dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	14592837	GOA
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	21051556	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of pseudopodium assembly	IDA IDA: Inferred from direct assay	11242036	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	14592837	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	14592837	GOA
involved in ruffle organization	IDA IDA: Inferred from direct assay	15569314	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL21 Protein Structure

IL8

0
100
134 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 21	Efficient Chemoattractant for Lymphocytes

CCL21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL21	O00585	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	CCL21	O00585	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CCL21	O00585	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CCL21	O00585	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CCL21	O00585	PF4V1	Homo sapiens	P10720	Filter Binding	28381538
Intra	CCL21	O00585	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	CCL21	O00585	OTP	Homo sapiens	Q5XKR4	Y2H Prey Pooling	32296183
Intra	CCL21	O00585	OTP	Homo sapiens	Q5XKR4	Validated Y2H	32296183
Intra	CCL21	O00585	OTP	Homo sapiens	Q5XKR4	Y2H Array	32296183
Intra	CCL21	O00585	CCL17	Homo sapiens	Q92583	SPR	28381538
Intra	CCL21	O00585	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CCL21	O00585	CXCL14	Homo sapiens	O95715	Filter Binding	28381538
Intra	CCL21	O00585	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL21	O00585	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL21	O00585	CXCL9	Homo sapiens	Q07325	Filter Binding	28381538
Intra	CCL21	O00585	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CCL21	O00585	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CCL21	O00585	CCL28	Homo sapiens	Q9NRJ3	Filter Binding	28381538
Intra	CCL21	O00585	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538
Intra	CCL21	O00585	CXCL10	Homo sapiens	P02778	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7166	Exodus-2/CCL21 Protein, Human	O00585 (S24-P134)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72875	Exodus-2/CCL21 Protein, Human (sf9)	O00585 (S24-P134)	≥ 95%, as determined by reducing SDS-PAGE.

CCL21 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83030	CCL21 Antibody (YA2775)	WB	Human

Related Diseases

Diseases	Alias
Periapical Periodontitis	Apical Periodontitis Periodontitis Apical
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Scrapie
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120427	Cosalane	Antagonist	99.78%	Unkown
HY-RS02091	CCL21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174761	Human CCL21 mRNA		/	Unkown
HY-RS23188	Ccl21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992197	Anti-CCL21 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCL21	VGNC	VGNC:26948
Macaca mulatta	CCL21	VGNC	VGNC:104885
Felis catus	CCL21	VGNC	VGNC:60543
Rattus norvegicus	CCL21	RGD	RGD:1311996
Others	CCL21	NCBI