2. Gene
  3. DUSP26 - dual specificity phosphatase 26 Gene

DUSP26 - dual specificity phosphatase 26 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24

Gene ID: 78986 | Gene type: protein coding

About DUSP26

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:33,591,330-33,600,023 (from NCBI)

This gene has 3 transcripts (splice variants), 250 orthologues and 30 paralogues. Biased expression in heart (RPKM 15.4), brain (RPKM 12.7) and 8 other tissues.

Summary

This gene encodes a member of the tyrosine Phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

DUSP26 Products(3)

mRNA Protein Name
NM_001305115.2 NP_001292044.1 dual specificity protein phosphatase 26
NM_001305116.2 NP_001292045.1 dual specificity protein phosphatase 26
NM_024025.3 NP_076930.1 dual specificity protein phosphatase 26

DUSP26 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (69 - 203)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 26

MAP kinase phosphatase 8

Related Diseases

Diseases Alias
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18756 NSC-87877 ≥99.0% Unkown
HY-101510 F1063-0967 Inhibitor ≥98.0% Unkown
HY-18756A NSC-87877 disodium ≥98.0% Unkown
HY-RS04063 DUSP26 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DUSP26 RGD RGD:1310090
Bos taurus DUSP26 VGNC VGNC:28258
Canis familiaris DUSP26 VGNC VGNC:51798
Mus musculus DUSP26 MGD MGI:1914209
Macaca mulatta DUSP26 VGNC VGNC:71914