DUSP26 - dual specificity phosphatase 26 Gene

Also Known as LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 78986

About DUSP26

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:33,591,330-33,600,023 (from NCBI)

This gene has 3 transcripts (splice variants), 250 orthologues and 30 paralogues. Biased expression in heart (RPKM 15.4), brain (RPKM 12.7) and 8 other tissues.

Summary

This gene encodes a member of the tyrosine Phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

DUSP26 Products (3)

mRNA	Protein	Name
NM_001305115.2	NP_001292044.1	dual specificity protein phosphatase 26
NM_001305116.2	NP_001292045.1	dual specificity protein phosphatase 26
NM_024025.3	NP_076930.1	dual specificity protein phosphatase 26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16581800	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	20562916	GOA
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	19043453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20562916	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	20562916	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	15796912	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16581800	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16581800	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	19043453	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	19043453	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19043453	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15796912	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15796912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP26 Protein Structure

DSPc

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 26	MAP kinase phosphatase 8

DUSP26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUSP26	Q9BV47	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	DUSP26	Q9BV47	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	DUSP26	Q9BV47	TP53	Homo sapiens	P04637	Phosphatase Assay	20562916
Intra	DUSP26	Q9BV47	TP53	Homo sapiens	P04637	Anti Bait CoIP	20562916
Intra	DUSP26	Q9BV47	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	DUSP26	Q9BV47	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	DUSP26	Q9BV47	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	DUSP26	Q9BV47	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	DUSP26	Q9BV47	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	DUSP26	Q9BV47	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	DUSP26	Q9BV47	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	DUSP26	Q9BV47	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	DUSP26	Q9BV47	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18756	NSC-87877		≥99.0%	Unkown
HY-101510	F1063-0967	Inhibitor	99.30%	Unkown
HY-18756A	NSC-87877 disodium		98.0%	Unkown
HY-RS04063	DUSP26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP26	RGD	RGD:1310090
Bos taurus	DUSP26	VGNC	VGNC:28258
Canis familiaris	DUSP26	VGNC	VGNC:51798
Mus musculus	DUSP26	MGD	MGI:1914209
Macaca mulatta	DUSP26	VGNC	VGNC:71914
Others	DUSP26	NCBI