Glycerol-d3
Based on 1 Customer Validation
Glycerol-d3 is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
For research use only. We do not sell to patients.
- CAS No.: 7325-16-8
- Formula: C3H5D3O3
- Molecular Weight:95.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 7325-16-8
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Unlabeled CAS 56-81-5
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Molecular Weight 95.11
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Formula C3H5D3O3
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SMILES
[2H]OCC(O[2H])CO[2H]
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Synonyms
Trihydroxypropane-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Polyacrylamide gel electrophoresis (PAGE) (<1 kb)
Gel electrophoresis is a method for separating biological macromolecules (such as nucleic acids or proteins) by forcing them through a gel matrix under an electric field.
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Protocol for Protein Electrophoresis
Protein electrophoresis separates proteins in a polyacrylamide gel under an electric field; in SDS-PAGE, sodium dodecyl sulfate denatures proteins and gives them a broadly similar negative charge-to-mass ratio, so migration mainly reflects apparent molecular mass through the gel matrix. The readout is a stained protein band pattern: band position estimates apparent molecular mass using protein standards, band intensity reflects relative protein abundance within the linear range of staining/detection, and changes in band pattern can reflect protein expression, degradation, purification, or sample composition.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72. [Content Brief]
[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9. [Content Brief]
[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycerol-d3 Related Classifications
HY-B1659S8 Related Classifications
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