GRP78-IN-1
GRP78-IN-1 exhibits several interactions with GRP78 residues with binding energy of -8.07 kcal/mol. GRP78-IN-1 shows the potent cytotoxic, anti-proliferative in cancer cells. GRP78-IN-1 exhibits promising apoptosis in breast cancer cells and stalls wound healing properties.
For research use only. We do not sell to patients.
- Formula: C21H23FO3
- Molecular Weight:342.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Grp78 |
GRP78-IN-1 (compound 3i) (0.01, 0.1, 1, 10, 100 μM; 48 h) shows the most potent cytotoxic effect (IC50s of 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 μM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively)[1].
GRP78-IN-1 (1, 2, 4, 6 μM) shows a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells[1].
GRP78-IN-1 (1, 2, 4, 6 μM; 48 h) inhibits the motility of MCF-7 and A549 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-1, MDA-MB-231, PANC-1, HCT-116, PC-3, A549, FR-2cells
-
Concentration:0.01, 0.1, 1, 10, 100 µM
-
Incubation Time:48 h
-
Result:Showed the most promising cytotoxic effect (IC50s is 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively).
-
Cell Line:BCL-2, BAX, cleaved caspase 9, MCF-7, A549 cells
-
Concentration:1, 2, 4, 6 µM
-
Incubation Time:
-
Result:Showed a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells.
Chemical Information
-
Molecular Weight 342.40
-
Formula C21H23FO3
-
SMILES
[H][C@@]12CC[C@]3(O[C@H]3[C@@]14OC(C(CC5=CC=C(C=C5)F)=C4CC[C@H]2C)=O)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GRP78-IN-1 Related Classifications
HY-145857 Related Classifications
Powered by Bioz