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Cat. No.: HY-111239

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GSK317354A

GSK317354A is a ROCK and GRK inhibitor. GSK317354A can be used for heart failure and Parkinson’s disease research.

For research use only. We do not sell to patients.

CAS No.: 874119-13-8
Formula: C₂₅H₁₈F₄N₆O
Molecular Weight:494.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GSK317354A Chemical Structure

CAS No.: 874119-13-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GSK317354A is a ROCK and GRK inhibitor. GSK317354A can be used for heart failure and Parkinson’s disease research^[1].

IC₅₀ & Target

ROCK

All ROCK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	75 nM Compound: 16	Inhibition of human recombinant ROCK1 kinase expressed in insect Sf9 cells by SPA Inhibition of human recombinant ROCK1 kinase expressed in insect Sf9 cells by SPA	[PMID: 18842034]

Chemical Information

CAS No. 874119-13-8
Molecular Weight 494.44
Formula C₂₅H₁₈F₄N₆O
SMILES

O=C(C1=C(C)NC(C2=CC=C(C(F)(F)F)N=C2)=NC1C3=CC=C(F)C=C3)NC4=CC5=C(NN=C5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Homan KT, et al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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GSK317354A

All ROCK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GSK317354A Related Classifications

HY-111239 Related Classifications