Copy Link Print Information

LGK974

(Synonyms: WNT974)
47 Cited Publications
Customer Review

Based on 47 publication(s) in Google Scholar

LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 1243244-14-5
  • Formula: C23H20N6O
  • Molecular Weight:396.44
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • LGK974 Chemical Structure
    LGK974 Chemical Structure
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
CAS No.: 1243244-14-5
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Protocol
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) LGK974

More
Customer Validation & Images
Histological Imaging/StainingIn Vivo Efficacy StudyWBIF
  • Histological Imaging/Staining
  • Histological Imaging/Staining
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • IF
  • WB
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • LGK974 Chemical Structure
    LGK974 Chemical Structure
    1/16
  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.). Immunohistochemical staining of CD31 in RCAS/tv-a glioma from mice treated with or without LGK974 was performed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.). Co-immunofluorescence staining and quantification of β-catenin and CD31 in RCAS/tv-a glioma tumors from mice treated with or without LGK974 were performed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.) was administered. The survival curve of CT-2A glioma-bearing mice treated with LGK974 and/or TMZ was analyzed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Mar;53(3):407-421. [Abstract]

    Customer Validation
     C57BL/6 mice were injected i.p. with 0–60 mg/kg LGK974 2 h before being injected with 25 mg/kg LPS. Cytokine concentrations in the plasma were determined using a magnetic Luminex assay.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2020 Sep 3;27(3):413-429.e4. [Abstract]

    Customer Validation
     IF images of uninjured, 48 hpi, and 72 hpi mouse airway epithelia wild-type mice treated with vehicle or LGK974 assessing BrdU incorporation. Relative to vehicle-treated mice, LGK974-treated mice exhibited an attenuated SAE with few BrdU+ ABSCs, thereby phenocopying the repair response of K5-CreER;Ctnnb1fl/fl mouse tracheas.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2016 Jul 15;345(2):206-17. [Abstract]

    Customer Validation
     Inhibition of PORCN abolishes Runx2 induction stimulated by β-GP. VSMCs are pretreated with LGK974 (1nM) for 30 min, then incubated with β-GP (10mM) for 24h, and the cell lysates are immunoblotted with antibodies against Runx2 and β-actin, respectively.

  • LGK974