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Cat. No.: HY-112738

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AX048

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.

For research use only. We do not sell to patients.

CAS No.: 873079-69-7
Formula: C₂₂H₄₁NO₄
Molecular Weight:383.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

AX048 Chemical Structure

CAS No.: 873079-69-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy^[1].

IC₅₀ & Target

cPLA₂

All Phospholipase Isoforms :

In Vivo

AX048 (0-30 mg/kg, i.p.) reduces the thermal hyperalgesia with the ED₅₀ of 1.2 mg/kg in Sprague Dawle rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan-induced thermal hyperalgesia in Sprague Dawley rats^[1]
Dosage:

0-30 mg/kg
Administration:

i.p.
Result:

Reduced the escape latencies in a dose-dependent manner.

Chemical Information

CAS No. 873079-69-7
Molecular Weight 383.57
Formula C₂₂H₄₁NO₄
SMILES

O=C(C(CCCCCCCCCCCCCC)=O)NCCCC(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yaksh TL, et al., Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan;316(1):466-75. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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AX048

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AX048 Related Classifications

HY-112738 Related Classifications