Ocankitug
Based on 1 Customer Validation
Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.
For research use only. We do not sell to patients.
- Purity : ≥99.0%
- CAS No.: 2803351-66-6
- Molecular Weight:145.32 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
|
IL7R |
In Vitro
Ocankitug binds to TSLP with high affinity, blocking its interaction with the receptor (TSLPR/IL-7Rα), thereby inhibiting the activation of downstream dendritic cells, Th2 cells, and eosinophils, and interfering with the type 2 inflammatory pathway at its source.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Q969D9-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized TSLP Protein, Human (HEK293, His, HY-P70818) can bind Ocankitug. The EC50 for this effect is 2.541 ng/mL.
Chemical Information
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CAS No. 2803351-66-6
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Appearance Liquid
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Molecular Weight 145.32 kDa
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Color Colorless to light yellow
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SMILES
[Ocankitug]
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Synonyms
CM-326
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (230 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)