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Cat. No.: HY-172674

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HPK1-IN-59

HPK1-IN-59 (compound 39) is an orally active HPK1 inhibitor with an IC₅₀ of 0.70 nM. HPK1-IN-59 has favorable oral bioavailability in mice.

For research use only. We do not sell to patients.

Formula: C₂₈H₃₁N₅O₄
Molecular Weight:501.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HPK1-IN-59 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

HPK1-IN-59 (compound 39) is an orally active HPK1 inhibitor with an IC₅₀ of 0.70 nM. HPK1-IN-59 has favorable oral bioavailability in mice^[1].

All MAP4K Isoforms :

Chemical Information

Molecular Weight 501.58
Formula C₂₈H₃₁N₅O₄
SMILES

CC(C)(C1=CC(C2=CN(N=C2)CC(C)(O)C)=CC3=CN=C(N=C31)NC4=CC(C(C)(O5)C)=C(C=C4)C5=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wan B, et al. Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity. J Med Chem. 2025 May 22;68(10):10439-10460. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HPK1-IN-59

All MAP4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HPK1-IN-59 Related Classifications

HY-172674 Related Classifications