2. MAPK/ERK Pathway
  3. MAP4K
  4. HPK1-IN-8

HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1.

For research use only. We do not sell to patients.

HPK1-IN-8 Chemical Structure

HPK1-IN-8 Chemical Structure

CAS No. : 1214561-09-7

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1 mg USD 750 In-stock
5 mg USD 2400 In-stock
10 mg USD 3850 In-stock
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Based on 1 publication(s) in Google Scholar

HPK1-IN-8 Related Antibodies

Top Publications Citing Use of Products

View All MAP4K Isoform Specific Products:

View All Isoforms
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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  • Purity & Documentation

  • References

  • Customer Review

Description

HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1.

Molecular Weight

412.44

Formula

C19H17FN6O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC=C(CC2=CC=CC=C2F)S1)CC3=C(C)N=C(NN=C4C)N4C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (24.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4246 mL 12.1230 mL 24.2460 mL
5 mM 0.4849 mL 2.4246 mL 4.8492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4246 mL 12.1230 mL 24.2460 mL 60.6149 mL
5 mM 0.4849 mL 2.4246 mL 4.8492 mL 12.1230 mL
10 mM 0.2425 mL 1.2123 mL 2.4246 mL 6.0615 mL
15 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0410 mL
20 mM 0.1212 mL 0.6061 mL 1.2123 mL 3.0307 mL
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HPK1-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-81214561-09-7MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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