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Cat. No.: HY-109023

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Azeloprazole

Azeloprazole is an orally active proton pump inhibitor. Azeloprazole irreversibly binds to and blocks the proton pump (H⁺/K⁺-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease.

For research use only. We do not sell to patients.

CAS No.: 955095-45-1
Formula: C₂₂H₂₇N₃O₄S
Molecular Weight:429.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Azeloprazole Chemical Structure

CAS No.: 955095-45-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vivo

Azeloprazole sodium (intraduodenal administration; single dose) inhibits Histamine (HY-B1204)-induced gastric acid secretion in a gastric fistula dog model, with a potency more than twice that of Esomeprazole^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Pharmacokinetic Study

Chemical Information

CAS No. 955095-45-1
Molecular Weight 429.53
Formula C₂₂H₂₇N₃O₄S
SMILES

CC(C(OCC1COC(C)(OC1)C)=C(C=N2)C)=C2C[S@](C3=NC4=CC=CC=C4N3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Srebro J, et al. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives. Pharmaceutics. 2022 Sep 25;14(10):2043.

[2]. Kinoshita Y, et al. Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study. Current therapeutic research, clinical and experimental. 2018;88:26-34.

[3]. Simadibrata DM, et al. Experimental drugs for erosive esophagitis: what is in the clinical development pipeline?. Expert opinion on investigational drugs. 2024 Oct;33(10):1009-1018.

[4]. Hunt RH, et al. Potent Acid Suppression with PPIs and P-CABs: What's New?. Current treatment options in gastroenterology. 2018 Dec;16(4):570-590.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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