Nidulalin A
Nidulalin A is a DNA topoisomerase II inhibitor with an IC50 of 2.2 μM. Nidulalin A has an IC50 of 172 μM for DNA topoisomerase I. Nidulalin A has certain cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 162901-86-2
- Formula: C16H14O6
- Molecular Weight:302.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.14 μM
Compound: 1 (Nidulalin A)
|
In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay
In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay
|
[PMID: 10509910] |
| K562 | IC50 |
0.32 μM
Compound: 1 (Nidulalin A)
|
In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay
In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay
|
[PMID: 10509910] |
| P388 | IC50 |
0.024 μM
Compound: 1 (Nidulalin A)
|
In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay
In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay
|
[PMID: 10509910] |
Chemical Information
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CAS No. 162901-86-2
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Molecular Weight 302.28
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Formula C16H14O6
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SMILES
COC([C@]12C(C(C3=C(O)C=C(C)C=C3O2)=O)=CC=C[C@H]1O)=O
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Structure Classification
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Initial Source
Penicillium sp. AJ117292
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)