1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IDO/TDO-IN-1

IDO/TDO-IN-1 

Cat. No.: HY-128355
Handling Instructions

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively .

For research use only. We do not sell to patients.

IDO/TDO-IN-1 Chemical Structure

IDO/TDO-IN-1 Chemical Structure

CAS No. : 2033173-01-0

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Description

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].

IC50 & Target

IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]

In Vitro

IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].

Molecular Weight

413.49

Formula

C₂₅H₂₄FN₅

CAS No.

2033173-01-0

SMILES

CN1N=CC(C2=CC=C(N3CCC([[email protected]@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IDO/TDO-IN-1
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