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Cat. No.: HY-187554

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IDP-73152

IDP-73152 is an orally active bacterial Peptide deformylase inhibitor and Antibiotic. IDP-73152 exhibits activity against Gram-positive bacteria. IDP-73152 can be used in the research of infections caused by Streptococcus pneumoniae, Enterococcus faecium and Staphylococcus aureus.

For research use only. We do not sell to patients.

CAS No.: 1091682-50-6
Formula: C₂₈H₄₁F₃N₄O₄
Molecular Weight:554.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDP-73152 Chemical Structure

CAS No.: 1091682-50-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

IDP-73152 (10 μM; 2 h) exhibits good permeability across Caco-2 cell monolayers with low efflux, as shown by P_app values of 31.2 × 10^-6 cm/s (A-to-B) and 49.5 × 10^-6 cm/s (B-to-A) and an efflux ratio <2^[3].
IDP-73152 (0.3 μM; 240 min) is unstable in rat blood, with a blood clearance of 0.0430 L/h/kg, which contributes minimally to overall systemic clearance in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	T_1/2	MRT	AUC_0-24	AUC_0-∞
Mice^[1]	80 mg/kg	p.o.	0.50 h	8950 ng/mL	2.70 h	4.50 h	46500 ng·h/mL	46600 ng·h/mL
Rat^[1]	80 mg/kg	p.o.	0.28 h	6300 ng/mL	2.89 h	4.86 h	31500 ng·h/mL	31600 ng·h/mL

In Vivo

IDP-73152 (p.o.; twice daily) produces 50% survival in infected mice with ED₅₀ values of 3.0 mg/kg (penicillin-resistant Streptococcus pneumoniae), 13.3 mg/kg (vancomycin-resistant Enterococcus faecium), and 16.6 mg/kg (methicillin-resistant Staphylococcus aureus)^[2].
IDP-73152 (p.o.; twice daily) exhibits in vivo antibacterial efficacy in infected mice, with ED₅₀ values for survival of 3.0 mg/kg, 13.3 mg/kg, and 16.6 mg/kg against penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecium, and methicillin-resistant Staphylococcus aureus, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain^[2]
Dosage:

Various dosages
Administration:

p.o.; twice daily
Result:

Achieved an ED₅₀ of 3.0 mg/kg in penicillin-resistant Streptococcus pneumoniae-infected mice.
Achieved an ED₅₀ of 13.3 mg/kg in vancomycin-resistant Enterococcus faecium-infected mice.
Achieved an ED₅₀ of 16.6 mg/kg in methicillin-resistant Staphylococcus aureus-infected mice.

Chemical Information

CAS No. 1091682-50-6
Molecular Weight 554.66
Formula C₂₈H₄₁F₃N₄O₄
SMILES

[C@@H](C(N[C@H](C(=O)N1CCC(NCC2=C(F)C=C(F)C(F)=C2)CC1)C(C)(C)C)=O)(CC3CCCC3)CN(C=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee M, et al. Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2017 Oct 25;145:364-371.

[2]. 이명재. Physiologically-based pharmacokinetic modeling of a novel antibacterial drug (IDP-73152) for prediction of its pharmacokinetics in humans[D]. 서울대학교 대학원, 2022.

[3]. Lee M, et al. Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics. Pharmaceutics. 2022 May 28;14(6):1157.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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