IDP-73152 mesylate
IDP-73152 mesylate is an orally active bacterial Peptide deformylase inhibitor and Antibiotic. IDP-73152 mesylate exhibits activity against Gram-positive bacteria. IDP-73152 mesylate can be used in the research of infections caused by Streptococcus pneumoniae, Enterococcus faecium and Staphylococcus aureus.
For research use only. We do not sell to patients.
- CAS No.: 1936442-71-5
- Formula: C29H45F3N4O7S
- Molecular Weight:650.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
In Vitro
IDP-73152 (10 μM; 2 h) mesylate exhibits good permeability across Caco-2 cell monolayers with low efflux, as shown by Papp values of 31.2 × 10-6 cm/s (A-to-B) and 49.5 × 10-6 cm/s (B-to-A) and an efflux ratio <2[3].
IDP-73152 (0.3 μM; 240 min) mesylate is unstable in rat blood, with a blood clearance of 0.0430 L/h/kg, which contributes minimally to overall systemic clearance in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
IDP-73152 (p.o.; twice daily) mesylate exhibits in vivo antibacterial efficacy in infected mice, with ED50 values for survival of 3.0 mg/kg, 13.3 mg/kg, and 16.6 mg/kg against penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecium, and methicillin-resistant Staphylococcus aureus, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain[2]
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Dosage:Various dosages
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Administration:p.o.; twice daily
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Result:Achieved an ED50 of 3.0 mg/kg in penicillin-resistant Streptococcus pneumoniae-infected mice.
Achieved an ED50 of 13.3 mg/kg in vancomycin-resistant Enterococcus faecium-infected mice.
Achieved an ED50 of 16.6 mg/kg in methicillin-resistant Staphylococcus aureus-infected mice.
Chemical Information
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CAS No. 1936442-71-5
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Molecular Weight 650.75
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Formula C29H45F3N4O7S
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SMILES
CS(=O)(O)=O.O=C(N1CCC(CC1)NCC2=C(C=C(C(F)=C2)F)F)[C@H](C(C)(C)C)NC([C@@H](CN(O)C=O)CC3CCCC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDP-73152 mesylate Related Classifications
HY-187554A Related Classifications
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Keywords
- IDP-73152
- 1936442-71-5
- IDP73152
- IDP 73152
- Antibiotic
- Bacterial
- Caco-2 cell
- pneumonia
- bacterial peptide deformylase
- rat hepatocytes
- liver microsomes
- methicillin-resistant Staphylococcus aureus
- vancomycin-resistant Enterococcus faecium
- skin infections
- Gram-positive bacteria
- penicillin-resistant Streptococcus pneumoniae
- Inhibitor
- inhibitor
- inhibit