Imbutamine

Imbutamine binds human H3R with pK_i 8.4^[1].
Imbutamine is a full agonist at human H3R in a cAMP accumulation assay with pEC₅₀ 8.3 and α 1.0^[1].
Imbutamine binds the human H3 receptor in SK-N-MC cell membranes with pK_i 8.4^[2].
Imbutamine binds the human H4 receptor in SK-N-MC cell membranes with pK_i 7.8 and shows 3.6-fold selectivity for human H3 over human H4^[2].
Imbutamine (6 h) acts as a full agonist at the human H3 receptor in SK-N-MC cells with pEC₅₀ 8.1^[2].
Imbutamine (1×10^-5-1×10^-12 M; 5 min) shows moderate isoform bias toward hH3R-445 over hH3R-329 and favors hH3R-415 over hH3R-329 in HEK293T cells expressing hH3R isoforms in CAMYEL BRET cAMP inhibition assays^[4].
Imbutamine has K_i values of 12.7 nM and 4.3 nM at recombinant human histamine H4 and H3 receptors, respectively^[5].
Imbutamine is a potent agonist at Sf9 membrane-expressed hH3R (EC₅₀ 3.13 nM) and hH4R (EC₅₀ 66.1 nM), with higher potency at hH3R^[6].
Imbutamine (60 min) binds hH3R with K_i 4.27 nM and hH4R with K_i 12.7 nM in Sf9 membrane preparations^[6].