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GLX351322

55 Cited Publications
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Based on 55 publication(s) in Google Scholar

GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

For research use only. We do not sell to patients.

  • Purity: 99.48%
  • CAS No.: 835598-94-2
  • Formula: C21H25N3O5S
  • Molecular Weight:431.51
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • GLX351322 Chemical Structure
    GLX351322 Chemical Structure
  • Experimental Validation Results for GLX351322
  • Experimental Validation Results for GLX351322
  • Experimental Validation Results for GLX351322
  • Experimental Validation Results for GLX351322
  • Experimental Validation Results for GLX351322
  • Experimental Validation Results for GLX351322
CAS No.: 835598-94-2
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Bio/Physico-chemical AssayIFFlow CytometryCell Proliferation/Viability AssayCell Imaging/StainingWB
  • Bio/Physico-chemical Assay
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  • Flow Cytometry
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
  • WB

All NADPH Oxidase Isoforms

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  • GLX351322 Chemical Structure
    GLX351322 Chemical Structure
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    GLX351322 purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Apr 9;33(4):529-544.e9. [Abstract]

    Customer Validation
     GLX351322 (10 μM; 6 h) impaired IFN-I-mediated control of P. berghei infection in primary mouse (B6) hepatocyte cultures.

  • 1/16

    GLX351322 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e13299. [Abstract]

    Customer Validation
     Representative immunofluorescence images of ROS in C166 cells subjected to 0.4 mM H2O2 following NOX4 enzyme inhibition by GLX351322 (20 µM; 24 h) .

  • 1/16

    GLX351322 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e13299. [Abstract]

    Customer Validation
     Flow cytometry quantification of ROS in C166 cells subjected to 0.4 mM H2O2 following NOX4 enzyme inhibition by GLX351322 (20 µM; 24 h).

  • 1/16

    GLX351322 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e13299. [Abstract]

    Customer Validation
     Cell viability of C166 cells subjected to 0.4 mM H2O2 with or without GLX351322 (20 µM; 24 h) pretreatment.

  • 1/16

    GLX351322 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e13299. [Abstract]

    Customer Validation
     GLX351322 (20 µM). Assessment of intracellular ROS levels in C166 cells by fluorescence microscopy (DCFH-DA staining) following H2O2 challenge.

  • 1/16

    GLX351322 purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Feb;24(4):2552-2565. [Abstract]

    Customer Validation
     GLX351322 on the level of phospho-p38 MAPK in VCR-treated cells (*P < .05, NAC/VCR-treated cells compared to VCR-treated cells; GLX351322/VCR-treated cells compared to VCR-treated cells).

  • GLX351322