DCBA-d10
DCBA-d10 is the d10-labeled DCBA (HY-136612). DCBA is the major urinary oxidative metabolite of the insect repellent DEET (HY-B0978). DCBA targets EGFR. DCBA exposure is significantly positively correlated with the risk of liver fibrosis. DCBA can be used in liver fibrosis research.
For research use only. We do not sell to patients.
- Formula: C12H5D10NO3
- Molecular Weight:231.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
Drug Metabolite[1]
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 72236-23-8
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Molecular Weight 231.31
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Formula C12H5D10NO3
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SMILES
OC(C1=CC(C(N(C([2H])(C([2H])([2H])[2H])[2H])C([2H])(C([2H])([2H])[2H])[2H])=O)=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lewis RC, et al. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environmental health : a global access science source. 2014 Nov 19;13:97. [Content Brief]
[2]. Kuklenyik P, et al. On-line solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry approach to quantify N,N-diethyl-m-toluamide and oxidative metabolites in urine. Anal Chim Acta. 2013 Jul 17;787:267-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DCBA-d10 Related Classifications
HY-W706930 Related Classifications
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Keywords
- DCBA-d10
- Isotope-Labeled Compounds
- Drug Metabolite
- EGFR
- MAPK signaling
- PI3K-Akt
- aldehyde intermediate
- benzyl methyl group
- exposure biomarker
- human urine
- inflammatory
- insect repellent
- liver fibrosis
- on-line SPE-HPLC-APCI-MS/MS
- oxidation
- oxidative stress pathways
- pregnant women
- pro-fibrogenic effects
- receptor tyrosine kinase
- ring-carboxylic acid
- urinary oxidative metabolite
- Inhibitor
- inhibitor
- inhibit