Cat. No.: HY-N0650

L-Serine

(Synonyms: Serine)

15 Cited Publications

Customer Review

Based on 15 publication(s) in Google Scholar

L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

For research use only. We do not sell to patients.

Purity: 99.95%
CAS No.: 56-45-1
Formula: C₃H₇NO₃
Molecular Weight:105.09

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

L-Serine Chemical Structure

CAS No.: 56-45-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Publications (15)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. In cell cultures, L-Serine is a conditionally essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization.L-Serine and the products of its metabolism have been recognized not only to be essential for cell proliferation but also to be necessary for specific functions in the central nervous system^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 56-45-1
Appearance Solid
Molecular Weight 105.09
Formula C₃H₇NO₃
Color White to off-white
SMILES

N[C@@H](CO)C(O)=O
Synonyms

Serine
Structure Classification
- Amino acids
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (15)

All IFIHCWBRT-PCRIn Vivo Efficacy Study

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Host Microbe

Microbiota-driven gut-brain signaling underlies antidepressant effects of a GLP-1 analog. [Abstract]

2026 Jun 10;34(6):1000-1017.e5. PMID: 42269582
Redox Biol

Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]

2024 May:71:103112. PMID: 38461791
Acta Pharm Sin B

Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1 α/NF- κ B feedback pathway to inhibit liver fibrosis. [Abstract]

2022 Sep;12(9):3618-3638. PMID: 36176909
Biomaterials

Ultrasound-responsive renal-targeted nanoparticles deliver TAK-242 to inhibit NF-κB/NLRP3 signaling and attenuate sepsis-associated acute kidney injury. [Abstract]

2025 Dec 14:329:123922. PMID: 41481962
Food Chem

Multi-omics reveals molecular basis of beef quality differences between Qinchuan and Nanyang cattle. [Abstract]

2026 Apr 6:12:100401. PMID: 42011267
Ecotoxicol Environ Saf

The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice. [Abstract]

2024 Nov 1:286:117216. PMID: 39437518

L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Nov 1:286:117216. [Abstract]

L-serine (50 g/L; drinking water administration). Immunohistochemical staining of CD68 (macrophage marker).
Ecotoxicol Environ Saf

The role of neutrophil extracellular traps in β-methylamino L-alanine-induced liver injury in mice. [Abstract]

2024 Jul 2:281:116678. PMID: 38964067

L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]

L-serine (300 mg/kg; i.v.). Immunofluorescence staining of Ly6G and citH3 in different groups of liver tissues.

L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]

L-serine (300 mg/kg; i.v.). Changes of Cleaved-Caspase 3, NETs formation-associated proteins citH3 and MPO, ERK/p38 signaling pathway proteins in different groups.

L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]

L-serine (300 mg/kg; i.v.). qRT-PCR was applied for determine the expression of TNF-α in different groups.

L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]

L-serine (300 mg/kg; i.v.). DNA content in serum of different groups of mice.
Molecules

Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]

2025 Mar 9;30(6):1224. PMID: 40142001
Naunyn Schmiedebergs Arch Pharmacol

Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine. [Abstract]

2025 Dec 18. PMID: 41408483
J Diabetes Investig

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy. [Abstract]

2025 May;16(5):775-790. PMID: 39992052
Amino Acids

Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]

2024 Sep 18;56(1):56. PMID: 39292313
Physiol Rep

Metabolic shifts in plasma amino acids and related metabolites in response to SGLT2 inhibition and hyperglycemia in type 1 diabetes. [Abstract]

2025 Aug;13(16):e70465. PMID: 40842430
bioRxiv

2025 July 15.
Research Square Print

2022 May.

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (475.78 mM; Need ultrasonic)

Methanol : < 1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

9.5157 mL

47.5783 mL

95.1565 mL

5 mM

1.9031 mL

9.5157 mL

19.0313 mL

10 mM

0.9516 mL

4.7578 mL

9.5157 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (951.57 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. de Koning TJ, et al. L-Serine in disease and development. Biochem J. 2003 May 1;371(Pt 3):653-61. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	9.5157 mL	47.5783 mL	95.1565 mL	237.8913 mL
	5 mM	1.9031 mL	9.5157 mL	19.0313 mL	47.5783 mL
	10 mM	0.9516 mL	4.7578 mL	9.5157 mL	23.7891 mL
	15 mM	0.6344 mL	3.1719 mL	6.3438 mL	15.8594 mL
	20 mM	0.4758 mL	2.3789 mL	4.7578 mL	11.8946 mL
	25 mM	0.3806 mL	1.9031 mL	3.8063 mL	9.5157 mL
	30 mM	0.3172 mL	1.5859 mL	3.1719 mL	7.9297 mL
	40 mM	0.2379 mL	1.1895 mL	2.3789 mL	5.9473 mL
	50 mM	0.1903 mL	0.9516 mL	1.9031 mL	4.7578 mL
	60 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9649 mL
	80 mM	0.1189 mL	0.5947 mL	1.1895 mL	2.9736 mL
	100 mM	0.0952 mL	0.4758 mL	0.9516 mL	2.3789 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Serine

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Publications Citing Use of MedChemExpress (MCE) L-Serine

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (15)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Serine Related Classifications

HY-N0650 Related Classifications