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Cat. No.: HY-120090

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MRS1177

MRS1177 is a potent and selective human Adenosine A3 receptor (hA₃AR) antagonist, with a K_i of 0.3 nM.

For research use only. We do not sell to patients.

CAS No.: 183721-13-3
Formula: C₂₀H₁₂ClN₅O₂
Molecular Weight:389.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MRS1177 Chemical Structure

CAS No.: 183721-13-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MRS1177 is a potent and selective human Adenosine A3 receptor (hA₃AR) antagonist, with a K_i of 0.3 nM.

IC₅₀ & Target

Ki: 0.3 nM (hA₃AR)^[1]^[2].

All Adenosine Receptor Isoforms :

In Vitro

MRS1177 (compound 2b) is a potent and selective human Adenosine A3 receptor (hA₃AR) antagonist^[1]. The K_i value of MRS1177 (compound 55) with hA₃AR is 0.3 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 183721-13-3
Molecular Weight 389.79
Formula C₂₀H₁₂ClN₅O₂
SMILES

O=C(C1=CC=CC=C1)NC2=NC3=C(C4=NC(C5=CC=CO5)=NN24)C=C(C=C3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. [Content Brief]

[2]. Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MRS1177

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MRS1177 Related Classifications

HY-120090 Related Classifications