SMO - smoothened, frizzled class receptor Gene

Also Known as Gx; CRJS; PHLS; SMOH; FZD11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6608

About SMO

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:129,188,633-129,213,545 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues, 15 paralogues and is associated with 118 phenotypes. Broad expression in ovary (RPKM 15.6), endometrium (RPKM 13.9) and 24 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for Hedgehog proteins. The encoded protein tranduces signals to Other proteins after activation by a Hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

SMO Products (2)

mRNA	Protein	Name
NM_005631.5	NP_005622.1	smoothened homolog precursor
XM_047420759.1	XP_047276715.1	smoothened homolog isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	36202993	GOA
enables patched binding	IPI IPI: Inferred from physical interaction	9811851	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19592253	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in contact inhibition	IMP IMP: Inferred from mutant phenotype	9422511	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21671467	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21671467	GOA
involved in smooth muscle tissue development	IEP IEP: Inferred from expression pattern	17850284	GOA
involved in smoothened signaling pathway	IDA IDA: Inferred from direct assay	36202993	GOA
involved in smoothened signaling pathway	IEP IEP: Inferred from expression pattern	17850284	GOA
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	9422511	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	11278759	GOA
colocalizes with caveola	IDA IDA: Inferred from direct assay	11278759	GOA
located in cilium	IDA IDA: Inferred from direct assay	27727273	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	11278759	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19304771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMO Protein Structure

Frizzled

0
200
400
600
787 a.a.

Protein Preferred Names	Protein Names
smoothened homolog	frizzled family member 11 protein Gx seven transmembrane helix receptor smoothened, frizzled family receptor smoothened, seven transmembrane spanning receptor

SMO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811088	Smoothened Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Joubert Syndrome 32	JBTS32
Skull Base Meningioma	Meningioma Of The Skull Base
Medullomyoblastoma
Brain Meningioma	Intracranial Meningioma
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Congenital Megacolon Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against Hirschsprung'S Disease Congenital Intestinal Aganglionosis HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Alkaptonuria	Homogentisic Acid Oxidase Deficiency Alcaptonuria AKU Deficiency Of Homogentisicase Homogentisate 1,2-Dioxygenase Deficiency Alkaptonuric Ochronosis Homogentisic Acidura Ochronosis, Hereditary Hereditary Ochronosis Ochronosis Homogentisicaciduria Deficiency Of Homogentisate Oxygenase
Cerebral Meningioma	Meningioma Of Cerebrum
Ameloblastoma	Adenoameloblastoma
Pallister-Hall-Like Syndrome	Hamartoma Of Hypothalamus PHLS Hypothalamic Hamartomas
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Holoprosencephaly 7	HPE7 Holoprosencephaly-7 Holoprosencephaly, Type 7
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Hydrolethalus Syndrome 2	HLS2 Hydrolethalus Syndrome, Type 2
Curry-Jones Syndrome	Craniofacial Malformations, Asymmetric, With Polysyndactyly And Abnormal Skin And Gut Development CRJS Curry-Jones Syndrome, Somatic Mosaic Curry Jones Syndrome Corpus Callosum Agenesis Polysyndactyly Corpus Callosum Agenesis-Polysyndactyly Syndrome Winter Shortland Temple Syndrome
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Basal Cell Carcinoma 1	Basal Cell Carcinoma, Susceptibility To, 1 Basal Cell Carcinoma BCC1 BCC Multiple Basal Cell Carcinoma Non-Syndromic Basal Cell Carcinoma Carcinoma, Basal Cell, Susceptibility To, Type 1 Experimental Organism Basal Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.98%	Yes
HY-16391	Glasdegib	Inhibitor	99.65%	Yes
HY-B0603	Fluticasone	Agonist	98.70%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.97%	Yes
HY-B0877	Halcinonide	Agonist	98.29%	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13654	IPI-269609	Inhibitor	/	Phase 4
HY-16587	Saridegib	Inhibitor	99.95%	Phase 3
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2
HY-13809	BMS-833923	Inhibitor	99.82%	Phase 2
HY-18636	LEQ506	Inhibitor	98.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (58)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.94%	Unkown
HY-100224	SANT-1	Antagonist	99.87%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.91%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	98.23%	Unkown
HY-15483	DY131	Inhibitor	99.72%	Unkown
HY-100535	KAAD-Cyclopamine	Antagonist	≥96.0%	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	99.63%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-N0836	Jervine	Inhibitor	99.28%	Unkown
HY-12317	GSA-10	Agonist	≥98.0%	Unkown
HY-13459	PF-5274857	Antagonist	99.31%	Unkown
HY-15412	HhAntag		99.40%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-151115	JNJ-1289	Inhibitor	98.06%	Unkown
HY-12848R	SAG (Standard)	Agonist	99.56%	Unkown
HY-137115	BODIPY-Cyclopamine		98.91%	Unkown
HY-113965	CUR61414	Inhibitor	99.04%	Unkown
HY-115566	S1PL-IN-1	Antagonist	99.9%	Unkown
HY-100036	MK-4101	Antagonist	99.16%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-18287	MRT-83	Antagonist	99.27%	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-120499	AZD8542	Antagonist	99.49%	Unkown
HY-100224G	SANT-1 (GMP)	Antagonist	/	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	98.69%	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-16391S1	Glasdegib-d4	Inhibitor	/	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-177291	LAB687	Antagonist	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-183335	SMO-IN-6	Inhibitor	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-16391B	Glasdegib hydrochloride	Inhibitor	/	Unkown
HY-159893	SMO-IN-5	Inhibitor	/	Unkown
HY-110326	Smo antagonist M25	Antagonist	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-145918	MRT-14	Antagonist	98.91%	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-123752	MS-0022	Antagonist	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	98.12%	Unkown
HY-133974	7-keto-25-Hydroxycholesterol	Activator	/	Unkown
HY-117903A	MRT-92	Antagonist	/	Unkown
HY-184378	MDB5	Inhibitor	/	Unkown
HY-W338819	Clobetasol	Agonist	/	Unkown
HY-12848G	SAG (GMP)	Agonist	/	Unkown
HY-16587A	Saridegib hydrochloride	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SMO	VGNC	VGNC:46565
Mus musculus	SMO	MGD	MGI:108075
Felis catus	SMO	VGNC	VGNC:80721
Bos taurus	SMO	VGNC	VGNC:35025
Rattus norvegicus	SMO	RGD	RGD:3726
Macaca mulatta	SMO	VGNC	VGNC:77658
Others	SMO	NCBI