EAF1 - ELL associated factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85403

About EAF1

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,427,598-15,442,613 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 21.6), brain (RPKM 8.9) and 25 other tissues.

Summary

Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

EAF1 Products (1)

mRNA Protein Name
NM_033083.7 NP_149074.3 ELL-associated factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables transcription elongation factor activity IMP
IMP: Inferred from mutant phenotype
32087315 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
32087315 GOA
Cellular Component GO Annotation Evidence References Source
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
22195968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EAF1 Protein Structure

EAF

EAF: RNA polymerase II transcription elongation factor (13 - 114)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

ELL-associated factor 1

  • ELL (eleven nineteen lysine-rich leukemia gene)-associated factor 1

EAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EAF1 Q96JC9 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
25416956
Intra
EAF1 Q96JC9 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
25416956
Intra
EAF1 Q96JC9 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
25416956
Intra
EAF1 Q96JC9 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
25416956
Intra
EAF1 Q96JC9 MAB21L3 Homo sapiens Q8N8X9
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 MAB21L3 Homo sapiens Q8N8X9
Y2H Array
32296183
Intra
EAF1 Q96JC9 TNFAIP8 Homo sapiens O95379
Y2H Array
32296183
Intra
EAF1 Q96JC9 TNFAIP8 Homo sapiens O95379
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
EAF1 Q96JC9 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
EAF1 Q96JC9 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ARID4B Homo sapiens Q4LE39-3
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ARID4B Homo sapiens Q4LE39-3
Y2H Array
32296183
Intra
EAF1 Q96JC9 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
EAF1 Q96JC9 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
Intra
EAF1 Q96JC9 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 CCDC150 Homo sapiens Q8NCX0-3
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 CCDC150 Homo sapiens Q8NCX0-3
Y2H Array
32296183
Intra
EAF1 Q96JC9 SEMG1 Homo sapiens P04279-2
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 SEMG1 Homo sapiens P04279-2
Y2H Array
32296183
Intra
EAF1 Q96JC9 GRHL3 Homo sapiens Q8TE85-2
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GRHL3 Homo sapiens Q8TE85-2
Y2H Array
32296183
Intra
EAF1 Q96JC9 FAM228A Homo sapiens Q86W67
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 FAM228A Homo sapiens Q86W67
Y2H Array
32296183
Intra
EAF1 Q96JC9 GCSAML Homo sapiens Q5JQS6
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GCSAML Homo sapiens Q5JQS6
Y2H Array
32296183
Intra
EAF1 Q96JC9 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra
EAF1 Q96JC9 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra
EAF1 Q96JC9 DNTTIP1 Homo sapiens Q9H147
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 DNTTIP1 Homo sapiens Q9H147
Validated Y2H
32296183
Intra
EAF1 Q96JC9 DNTTIP1 Homo sapiens Q9H147
Y2H Array
32296183
Intra
EAF1 Q96JC9 ZNF143 Homo sapiens P52747
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ZNF143 Homo sapiens P52747
Y2H Array
32296183
Intra
EAF1 Q96JC9 AP2M1 Homo sapiens Q96CW1
Y2H Array
32296183
Intra
EAF1 Q96JC9 AP2M1 Homo sapiens Q96CW1
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra
EAF1 Q96JC9 SRP14 Homo sapiens P37108
Y2H Array
32296183
Intra
EAF1 Q96JC9 SRP14 Homo sapiens P37108
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 PSME3 Homo sapiens P61289
Y2H Array
25416956
Intra
EAF1 Q96JC9 PSME3 Homo sapiens P61289
BFG-2H
27107012
Intra
EAF1 Q96JC9 PSME3 Homo sapiens P61289
Y2H Array
32296183
Intra
EAF1 Q96JC9 PSME3 Homo sapiens P61289
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
EAF1 Q96JC9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra
EAF1 Q96JC9 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
EAF1 Q96JC9 GADD45GIP1 Homo sapiens Q8TAE8
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GADD45GIP1 Homo sapiens Q8TAE8
Y2H Array
32296183
Intra
EAF1 Q96JC9 ELL2 Homo sapiens O00472
Anti Tag CoIP
33961781
Intra
EAF1 Q96JC9 ELL2 Homo sapiens O00472
Anti Tag CoIP
28514442
Intra
EAF1 Q96JC9 ELL2 Homo sapiens O00472
Y2H Array
32296183
Intra
EAF1 Q96JC9 ELL2 Homo sapiens O00472
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ELL2 Homo sapiens O00472
Anti Tag CoIP
21729782
Intra
EAF1 Q96JC9 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
EAF1 Q96JC9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
EAF1 Q96JC9 GTF2H4 Homo sapiens Q92759
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 GTF2H4 Homo sapiens Q92759
Y2H Array
32296183
Intra
EAF1 Q96JC9 TRIM62 Homo sapiens Q9BVG3
Validated Y2H
32296183
Intra
EAF1 Q96JC9 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra
EAF1 Q96JC9 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra
EAF1 Q96JC9 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
EAF1 Q96JC9 ELL3 Homo sapiens Q9HB65
Anti Tag CoIP
21729782
Intra
EAF1 Q96JC9 ELL3 Homo sapiens Q9HB65
Anti Tag CoIP
33961781
Intra
EAF1 Q96JC9 ELL3 Homo sapiens Q9HB65
Anti Tag CoIP
28514442
Intra
EAF1 Q96JC9 ELL3 Homo sapiens Q9HB65
Validated Y2H
32296183
Intra
EAF1 Q96JC9 GTF2H1 Homo sapiens P32780
Y2H Array
32296183
Intra
EAF1 Q96JC9 GTF2H1 Homo sapiens P32780
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 TFCP2 Homo sapiens Q12800
Validated Y2H
25416956
Intra
EAF1 Q96JC9 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
EAF1 Q96JC9 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
EAF1 Q96JC9 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
EAF1 Q96JC9 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra
EAF1 Q96JC9 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 STAC3 Homo sapiens Q96MF2
Y2H Array
32296183
Intra
EAF1 Q96JC9 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra
EAF1 Q96JC9 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
EAF1 Q96JC9 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra
EAF1 Q96JC9 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
EAF1 Q96JC9 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
EAF1 Q96JC9 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
Intra
EAF1 Q96JC9 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ZNF202 Homo sapiens O95125
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 ZNF202 Homo sapiens O95125
Y2H Array
32296183
Intra
EAF1 Q96JC9 RYBP Homo sapiens Q8N488
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 RYBP Homo sapiens Q8N488
Y2H Array
32296183
Intra
EAF1 Q96JC9 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
EAF1 Q96JC9 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
EAF1 Q96JC9 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eaf

  • Eosinophilic Angiocentric Fibrosis

  • Sinonasal Eosinophilic Angiocentric Fibrosis

  • Igg4-Related Eosinophilic Angiocentric Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04119 EAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13752 SRCAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19323 Eaf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25814 Eaf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EAF1 VGNC VGNC:61700
Bos taurus EAF1 VGNC VGNC:28294
Canis familiaris EAF1 VGNC VGNC:40171
Macaca mulatta EAF1 VGNC VGNC:71874
Rattus norvegicus EAF1 RGD RGD:1310057
Mus musculus EAF1 MGD MGI:1921677
Others EAF1 NCBI