PMMB-187
PMMB-187 is a selective STAT3 inhibitor with an IC50 value of 1.81 μM for MDA-MB-231 cells. PMMB-187 induces apoptosis (Apoptosis) in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity, nuclear translocation, and downstream target gene expression, while also reducing mitochondrial membrane potential, generating reactive oxygen species (ROS), and upregulating the expression levels of apoptosis-related proteins. PMMB-187 has potential applications in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2162952-37-4
- Formula: C27H23BrN2O6S2
- Molecular Weight:615.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Stat-3 1.81 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
86.9 μM
Compound: 1-62
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Cytotoxicity against human MCF-10A assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
Cytotoxicity against human MCF-10A assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
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[PMID: 35367708] |
| MCF7 | IC50 |
4.71 μM
Compound: 126
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
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[PMID: 38458106] |
| MCF7 | IC50 |
4.71 μM
Compound: 1-62
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
|
[PMID: 35367708] |
| MDA-MB-231 | IC50 |
1.81 μM
Compound: 126
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
|
[PMID: 38458106] |
| MDA-MB-231 | IC50 |
1.81 μM
Compound: 1-62
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
|
[PMID: 35367708] |
| MDA-MB-231 | IC50 |
1.81 μM
Compound: 35
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Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
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[PMID: 34170703] |
| MDA-MB-468 | IC50 |
2.99 μM
Compound: 126
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA
|
[PMID: 38458106] |
| MDA-MB-468 | IC50 |
2.99 μM
Compound: 1-62
|
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
|
[PMID: 35367708] |
Chemical Information
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CAS No. 2162952-37-4
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Molecular Weight 615.52
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Formula C27H23BrN2O6S2
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SMILES
O=C1C2=C(O)C=CC(O)=C2C(C=C1[C@@H](C/C=C(C)/C)OC(CSC3=NN=C(CC4=CC=C(C=C4)Br)S3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PMMB-187 Related Classifications
HY-164521 Related Classifications
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