2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK2-IN-12

JAK2-IN-12 (compound 23) is a JAK2 inhibitor with a pIC50 of 8.2. JAK2-IN-12 can be used for study of myelofibrosi.

For research use only. We do not sell to patients.

JAK2-IN-12

JAK2-IN-12 Chemical Structure

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JAK2-IN-12 Related Antibodies

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Description

JAK2-IN-12 (compound 23) is a JAK2 inhibitor with a pIC50 of 8.2. JAK2-IN-12 can be used for study of myelofibrosi[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 GI50
0.18 μM
Compound: 3
Growth inhibition of mouse BaF3 cells harboring JAK2 V617F mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells harboring JAK2 V617F mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38389874]
MV4-11 GI50
0.051 μM
Compound: 3
Growth inhibition of human MV4-11 cells by WST-8 assay
Growth inhibition of human MV4-11 cells by WST-8 assay
[PMID: 38389874]
Molecular Weight

486.61

Formula

C29H34N4O3
SMILES

CC1=C(C2=CC(COC/C=C/COCC3=C(OCCN4CCCC4)C=CC5=C3)=CC=C2)N=C(N5)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK2-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2-IN-12JAKJanus kinasemyelofibrosisInhibitorinhibitorinhibit

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HY-176479
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