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Cat. No.: HY-169634

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JD118

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135).

For research use only. We do not sell to patients.

CAS No.: 315704-83-7
Formula: C₁₃H₁₂N₄S₂
Molecular Weight:288.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JD118 Chemical Structure

CAS No.: 315704-83-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135)^[1].

All JNK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	44 μM Compound: 7	Antiproliferative activity against MCF7 cells after 72 hrs Antiproliferative activity against MCF7 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	55 μM Compound: 7	Antiproliferative activity against SkBr3 cells after 72 hrs Antiproliferative activity against SkBr3 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	61 μM Compound: 7	Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA	[PMID: 17223347]

Chemical Information

CAS No. 315704-83-7
Molecular Weight 288.39
Formula C₁₃H₁₂N₄S₂
SMILES

CC1=C(SC(N)=N1)C2=CSC(NC3=CC=CC=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ngoei KR, et al. Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta. 2013;1834(6):1077-1088. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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JD118

High-Throughput Bioactive Compound Library

All JNK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JD118 Related Classifications

HY-169634 Related Classifications