5A2-SC8
Based on 1 publication(s) in Google Scholar
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 1857341-90-2
- Formula: C93H173N5O20S5
- Molecular Weight:1841.72
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 5A2-SC8
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Biological Activity
The ApoE protein corona adsorbs on the surface of 5A2-SC8 LNPs binds to LDL-R on the surface of hepatocytes and undergoes receptor-mediated endocytosis, and is taken up by hepatocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1857341-90-2
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Appearance Oil
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Molecular Weight 1841.72
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Formula C93H173N5O20S5
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Color Colorless to light yellow
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SMILES
O=C(CCN(CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceutics
2022 Oct 7;14(10):2129. PMID: 36297564
Solvent & Solubility
DMSO : 100 mg/mL (54.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525. [Content Brief]
[2]. Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022): 3973-3986. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5430 mL | 2.7149 mL | 5.4297 mL | 13.5743 mL |
| 5 mM | 0.1086 mL | 0.5430 mL | 1.0859 mL | 2.7149 mL | |
| 10 mM | 0.0543 mL | 0.2715 mL | 0.5430 mL | 1.3574 mL | |
| 15 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9050 mL | |
| 20 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6787 mL | |
| 25 mM | 0.0217 mL | 0.1086 mL | 0.2172 mL | 0.5430 mL | |
| 30 mM | 0.0181 mL | 0.0905 mL | 0.1810 mL | 0.4525 mL | |
| 40 mM | 0.0136 mL | 0.0679 mL | 0.1357 mL | 0.3394 mL | |
| 50 mM | 0.0109 mL | 0.0543 mL | 0.1086 mL | 0.2715 mL |
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