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Cat. No.: HY-19638

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Cangrelor

(Synonyms: AR-C69931MX)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist.

For research use only. We do not sell to patients.

CAS No.: 163706-06-7
Formula: C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂
Molecular Weight:776.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Cangrelor Chemical Structure

CAS No.: 163706-06-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

P2Y12 Receptor

All P2Y Receptor Isoforms :

In Vitro

Cangrelor tetrasodium has pK_b of 8.6-9.2 for hP2Y12 receptor^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 163706-06-7
Molecular Weight 776.36
Formula C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂
SMILES

CSCCNC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O)(O)=O)(O)=O)(O)=O)O3)C=N2)=NC(SCCC(F)(F)F)=N1
Synonyms

AR-C69931MX
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All ELISACell Proliferation/Viability AssayWBIn Vivo Efficacy Study

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Journal Impact Factor

Cell Rep

ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. [Abstract]

2024 Nov 9;43(11):114962. PMID: 39522165
Biochem Pharmacol

Efficient screening and evaluation of MRGPRX2 antagonists based on AlphaFold 3. [Abstract]

2025 Oct 23:117451. PMID: 41138926

Cangrelor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451. [Abstract]

Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC₅₀ values in Huh7 and Hep3B cells.
Int J Mol Sci

Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]

2025 Feb 6;26(3):1381. PMID: 39941149

Cangrelor purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]

Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.
Mol Nutr Food Res

A Collagen-Derived Oligopeptide from Salmo salar Collagen Hydrolysates Restrains Atherogenesis in ApoE-/- Mice via Targeting P2 Y12 Receptor. [Abstract]

2022 Jul;66(13):e2200166. PMID: 35490399

Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.

Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408. [Content Brief]

[2]. Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92. [Content Brief]

[3]. Bekő K, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain. J Thromb Haemost. 2017;15(6):1223-1235. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Purity & Documentation
References

1/16
1/16

Cangrelor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451. [Abstract]

Customer Validation
Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC₅₀ values in Huh7 and Hep3B cells.
1/16

Cangrelor purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]

Customer Validation
Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.
1/16

Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

Customer Validation
The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.
1/16

Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

Customer Validation
Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

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Cangrelor

Publications Citing Use of MedChemExpress (MCE) Cangrelor

All P2Y Receptor Isoforms